Gemfibrozil and Pitavastatin Interaction
Drug interaction information between Gemfibrozil and Pitavastatin.
Gemfibrozil and Pitavastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Gemfibrozil and Pitavastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Gemfibrozil can cause muscle problems on its own, and the risk becomes even higher when it is mixed with a statin.
FDA Label Information
Gemfibrozil Clinical Impact: Gemfibrozil may cause myopathy when given alone. The risk of myopathy and rhabdomyolysis is increased with concomitant use of gemfibrozil with statins, including pitavastatin tablets. Intervention: Avoid concomitant use of gemfibrozil with pitavastatin tablets.
Gemfibrozil Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Repaglinide major
- Simvastatin major
- Atorvastatin moderate
Pitavastatin Also Interacts With
- Cyclosporine major
- Erythromycin major
- Rifampin major
- Colchicine moderate
- Niacin moderate
Frequently Asked Questions
What SPL severity band is on file for Gemfibrozil + Pitavastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Gemfibrozil has 20 labeled pairs on file vs Pitavastatin's 9. In the moderate band specifically: Gemfibrozil has 8 (also Atorvastatin, Eluxadoline, Fluvastatin, Lovastatin); Pitavastatin has 4 (also Colchicine, Niacin, Sofosbuvir/Velpatasvir).
What mechanism field is on file for Gemfibrozil and Pitavastatin?
Gemfibrozil can cause muscle problems on its own, and the risk becomes even higher when it is mixed with a statin.
Gemfibrozil carries more major-labeled pairs than Pitavastatin
SPL source-record counts only. This page's band is moderate · classes on file: Gemfibrozil (Fibrate); Pitavastatin (HMG-CoA Reductase Inhibitor (Statin)).
Gemfibrozil has 4 major-labeled pairs vs Pitavastatin's 3. This page itself is in the moderate band, not the major band.
4 major · 8 moderate · 8 minor · 20 total
- Other moderate peers for Gemfibrozil
- Atorvastatin
- Eluxadoline
- Fluvastatin
- Lovastatin
3 major · 4 moderate · 2 minor · 9 total
- Other moderate peers for Pitavastatin
- Colchicine
- Niacin
- Sofosbuvir/Velpatasvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.