Colestipol and Olmesartan Interaction
Drug interaction information between Colestipol and Olmesartan.
Colestipol and Olmesartan have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Colestipol and Olmesartan. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Colestipol can bind to other drugs in your stomach and stop them from getting into your blood. This means you might not get the full benefit of your blood pressure treatment.
FDA Label Information
7 DRUG INTERACTIONS Lithium: Risk of lithium toxicity ( 7.2 ) Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic and antihypotensive effects; increased risk of renal toxicity ( 7.3 ) Dual inhibition of the renin-angiotensin system: Increased risk of renal impairment, hypotension, and hyperkalemia ( 7.4 ) Colesevelam hydrochloride: Consider administering olmesartan at least 4 hours before colesevelam hydrochloride dose ( 7.5 ) Antidiabetic drugs: Dosage adjustment may be required ( 7.6 ) Cholestyramine and colestipol: Reduced absorption of thiazides ( 7.6 ) 7.1...
Colestipol Also Interacts With
- Furosemide minor
- Aspirin minor
- Propranolol minor
- Warfarin minor
- Clindamycin minor
Olmesartan Also Interacts With
- Aliskiren major
- Hydrochlorothiazide moderate
- Lithium moderate
- Colesevelam moderate
- Cholestyramine moderate
Frequently Asked Questions
What SPL severity band is on file for Colestipol + Olmesartan?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Colestipol has 24 labeled pairs on file vs Olmesartan's 7. In the moderate band specifically: Colestipol has 1; Olmesartan has 6 (also Hydrochlorothiazide, Lithium, Colesevelam, Cholestyramine).
What mechanism field is on file for Colestipol and Olmesartan?
Colestipol can bind to other drugs in your stomach and stop them from getting into your blood. This means you might not get the full benefit of your blood pressure treatment.
Olmesartan carries more major-labeled pairs than Colestipol
SPL source-record counts only. This page's band is moderate · classes on file: Colestipol (Bile Acid Sequestrant); Olmesartan (Angiotensin II Receptor Blocker (ARB)).
Olmesartan has 1 major-labeled pair vs Colestipol's 0. This page itself is in the moderate band, not the major band.
0 major · 1 moderate · 23 minor · 24 total
Colestipol has no other moderate-band peer in this dataset besides Olmesartan.
1 major · 6 moderate · 0 minor · 7 total
- Other moderate peers for Olmesartan
- Hydrochlorothiazide
- Lithium
- Colesevelam
- Cholestyramine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.