Colestipol and Warfarin Interaction
Drug interaction information between Colestipol and Warfarin.
Colestipol and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Colestipol and Warfarin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Colestipol does not seem to lower the levels of warfarin in your blood or stop it from being absorbed.
What To Do
You can take these medicines together as directed by your doctor. No special dose changes are typically required.
FDA Label Information
No depressant effect on blood levels in humans was noted when colestipol hydrochloride was administered with any of the following drugs: aspirin, clindamycin, clofibrate, methyldopa, nicotinic acid (niacin), tolbutamide, phenytoin or warfarin.
Colestipol Also Interacts With
- Olmesartan moderate
- Furosemide minor
- Aspirin minor
- Propranolol minor
- Clindamycin minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
Can I take Colestipol and Warfarin together?
This is a minor interaction. You can take these medicines together as directed by your doctor. No special dose changes are typically required.
How serious is the interaction between Colestipol and Warfarin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Colestipol and Warfarin interact?
Colestipol does not seem to lower the levels of warfarin in your blood or stop it from being absorbed.
Understanding the Colestipol and Warfarin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Colestipol belongs to the Bile Acid Sequestrant class and Warfarin belongs to the Vitamin K Antagonist (Anticoagulant) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Colestipol does not seem to lower the levels of warfarin in your blood or stop it from being absorbed. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Colestipol has 24 total documented interactions on file in this dataset, and Warfarin has 163. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You can take these medicines together as directed by your doctor. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Colestipol or Warfarin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.