Colestipol and Propranolol Interaction
Drug interaction information between Colestipol and Propranolol.
Colestipol and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Colestipol and Propranolol. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Colestipol can slow down how fast propranolol gets into your system, which might delay how quickly it starts working.
What To Do
Your doctor should watch you closely to make sure your heart medicine is still working as it should.
FDA Label Information
Repeated doses of colestipol hydrochloride given prior to a single dose of propranolol in human trials have been reported to decrease propranolol absorption. However, in a follow-up study in normal subjects, single-dose administration of colestipol hydrochloride and propranolol and twice-a-day administration for 5 days of both agents did not affect the extent of propranolol absorption, but had a small yet statistically significant effect on its rate of absorption; the time to reach maximum concentration was delayed approximately 30 minutes. Therefore, patients on propranolol should be...
Colestipol Also Interacts With
- Olmesartan moderate
- Furosemide minor
- Aspirin minor
- Warfarin minor
- Clindamycin minor
Frequently Asked Questions
Can I take Colestipol and Propranolol together?
This is a minor interaction. Your doctor should watch you closely to make sure your heart medicine is still working as it should.
How serious is the interaction between Colestipol and Propranolol?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Colestipol and Propranolol interact?
Colestipol can slow down how fast propranolol gets into your system, which might delay how quickly it starts working.
Understanding the Colestipol and Propranolol Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Colestipol belongs to the Bile Acid Sequestrant class and Propranolol belongs to the Non-Selective Beta-Blocker class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Colestipol can slow down how fast propranolol gets into your system, which might delay how quickly it starts working. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Colestipol has 24 total documented interactions on file in this dataset, and Propranolol has 44. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should watch you closely to make sure your heart medicine is still working as it should. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Colestipol or Propranolol based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.