Colestipol and Propranolol Interaction
Drug interaction information between Colestipol and Propranolol.
Colestipol and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Colestipol and Propranolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Colestipol can slow down how fast propranolol gets into your system, which might delay how quickly it starts working.
FDA Label Information
Repeated doses of colestipol hydrochloride given prior to a single dose of propranolol in human trials have been reported to decrease propranolol absorption. However, in a follow-up study in normal subjects, single-dose administration of colestipol hydrochloride and propranolol and twice-a-day administration for 5 days of both agents did not affect the extent of propranolol absorption, but had a small yet statistically significant effect on its rate of absorption; the time to reach maximum concentration was delayed approximately 30 minutes. Therefore, patients on propranolol should be...
Colestipol Also Interacts With
- Olmesartan moderate
- Furosemide minor
- Aspirin minor
- Warfarin minor
- Clindamycin minor
Frequently Asked Questions
What SPL severity band is on file for Colestipol + Propranolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propranolol has 44 labeled pairs on file vs Colestipol's 24. In the minor band specifically: Colestipol has 23 (also Furosemide, Aspirin, Warfarin, Clindamycin); Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil).
What mechanism field is on file for Colestipol and Propranolol?
Colestipol can slow down how fast propranolol gets into your system, which might delay how quickly it starts working.
Propranolol's labeled portfolio outnumbers Colestipol
SPL source-record counts only. This page's band is minor · classes on file: Colestipol (Bile Acid Sequestrant); Propranolol (Non-Selective Beta-Blocker).
0 major · 1 moderate · 23 minor · 24 total
- Other minor peers for Colestipol
- Furosemide
- Aspirin
- Warfarin
- Clindamycin
0 major · 0 moderate · 44 minor · 44 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.