Gabapentin and Morphine Interaction
Drug interaction information between Gabapentin and Morphine.
Gabapentin and Morphine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Gabapentin and Morphine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Morphine can raise the levels of gabapentin in your body, and both drugs can slow down your breathing.
FDA Label Information
7 DRUG INTERACTIONS Concentrations increased by morphine; may need dose adjustment (5.4, 7.1 ) 7.1 Opioids Respiratory depression and sedation, sometimes resulting in death, have been reported following coadministration of gabapentin with opioids (e.g., morphine, hydrocodone, oxycodone, buprenorphine) [ see Warnings and Precautions (5.7) ]. Morphine When gabapentin is administered with morphine, patients should be observed for signs of CNS depression, such as somnolence, sedation and respiratory depression [see Clinical Pharmacology (12.3) ]. 7.1 Opioids Respiratory depression and...
Gabapentin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Oxycodone minor
- Estradiol minor
- Naproxen minor
- Norethindrone minor
Morphine Also Interacts With
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Mirtazapine minor
- Verapamil minor
Frequently Asked Questions
What SPL severity band is on file for Gabapentin + Morphine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Morphine has 30 labeled pairs on file vs Gabapentin's 19. In the minor band specifically: Gabapentin has 18 (also Oxycodone, Estradiol, Naproxen, Norethindrone); Morphine has 30 (also Trazodone, Tramadol, Cyclobenzaprine, Mirtazapine).
What mechanism field is on file for Gabapentin and Morphine?
Morphine can raise the levels of gabapentin in your body, and both drugs can slow down your breathing.
Morphine's labeled portfolio outnumbers Gabapentin
SPL source-record counts only. This page's band is minor · classes on file: Gabapentin (Anticonvulsant / Nerve Pain Agent); Morphine (Opioid Analgesic).
0 major · 1 moderate · 18 minor · 19 total
- Other minor peers for Gabapentin
- Oxycodone
- Estradiol
- Naproxen
- Norethindrone
0 major · 0 moderate · 30 minor · 30 total
- Other minor peers for Morphine
- Trazodone
- Tramadol
- Cyclobenzaprine
- Mirtazapine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.