What the FDA labels say about taking them together
Gabapentin and morphine
Gabapentin's FDA label of May 12, 2026 names morphine in its drug interactions section, and morphine's label names gabapentin too. The morphine label: “Due to additive pharmacologic effect, the concomitant use of benzodiazepines or other CNS depressants, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death.”
Check it at the source: the gabapentin FDA label on DailyMed (effective May 12, 2026, Viatris Specialty LLC); the morphine FDA label on DailyMed (effective July 13, 2026, Bryant Ranch Prepack).
What does the gabapentin label say about morphine?
Gabapentin label, drug interactionsDRUG INTERACTIONS Concentrations increased by morphine; may need dose adjustment
Gabapentin label, warnings and precautionsIn addition, patients who require concomitant treatment with morphine may experience increases in gabapentin concentrations and may require dose adjustment [see Drug Interactions (7.1) ].
Gralise label (Almatica Pharma LLC, June 30, 2026), drug interactionsAn increase in gabapentin AUC values have been reported when administered with hydrocodone. ( 7.6 ) An increase in gabapentin AUC values have been reported when administered with morphine. ( 7.7 ) An antacid containing aluminum hydroxide and magnesium hydroxide reduced the bioavailability of gabapentin immediate release by about approximately 20%, but by only 5% when gabapentin was taken 2 hours after antacids.
Source: FDA drug label (Gralise, NDA022544), Almatica Pharma LLC, effective June 30, 2026 (SPL set 466273b1-c9fc-3930-c94b-aa11394d5140), via openFDA
Source: FDA drug label (Neurontin), Viatris Specialty LLC, effective May 12, 2026 (SPL set 97935fd9-1d4a-43b6-a5d9-de994591187b), via openFDA; the full label on DailyMed
What does the morphine label say about gabapentin?
Ms Contin label (Rhodes Pharmaceuticals LLC, August 14, 2026), drug interactionsBenzodiazepines and Other Central Nervous System (CNS) Depressants Clinical Impact: Due to additive pharmacologic effect, the concomitant use of benzodiazepines or other CNS depressants, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death. … sedative hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, alcohol.
Ms Contin label (Rhodes Pharmaceuticals LLC, August 14, 2026), warnings and precautionsRisks from Concomitant Use with Benzodiazepines or Other CNS Depressants Profound sedation, respiratory depression, coma, and death may result from the concomitant use of MS CONTIN with benzodiazepines and/or other CNS depressants, including alcohol (e.g., non-benzodiazepine sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids [gabapentin or pregabalin], and other opioids).
Morphine Sulfate label (Fresenius Kabi, USA LLC, August 31, 2026), drug interactionsBenzodiazepines and Other Central Nervous System (CNS) Depressants Clinical Impact: Due to additive pharmacologic effect, the concomitant use of benzodiazepines or other CNS depressants, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death. … sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, alcohol.
Source: FDA drug label (Ms Contin, NDA019516), Rhodes Pharmaceuticals LLC, effective August 14, 2026 (SPL set c354b3bf-86c0-4bb8-8b1f-be2164942698), via openFDA
Source: FDA drug label (Morphine Sulfate, NDA204223), Fresenius Kabi, USA LLC, effective August 31, 2026 (SPL set 1f53de80-efc8-4930-b3e3-fba0d026af05), via openFDA
Source: FDA drug label (Morphine sulfate), ANDA078761 (Sun Pharm Inds Ltd), as published by Bryant Ranch Prepack, effective July 13, 2026 (SPL set 595243fe-a4b1-479a-99d6-a084a4181891), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Gabapentin | Morphine | |
|---|---|---|
| Labeled for | Nerve pain and fibromyalgia, Seizures and epilepsy | Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0218 per capsule 100 mg capsule | $0.226 per tablet 15 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once