Fesoterodine and Estradiol Interaction
Drug interaction information between Fesoterodine and Estradiol.
Fesoterodine and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fesoterodine and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fesoterodine does not change the amount of estradiol in your blood, so the two drugs do not have a meaningful effect on each other.
FDA Label Information
7.6 Oral Contraceptives In the presence of fesoterodine, there are no clinically significant changes in the plasma concentrations of combined oral contraceptives containing ethinyl estradiol and levonorgestrel [see Clinical Pharmacology (12.3) ] .
Fesoterodine Also Interacts With
- Darunavir major
- Itraconazole major
- Ketoconazole moderate
- Clarithromycin moderate
- Diltiazem minor
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Fesoterodine + Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Fesoterodine's 15. In the minor band specifically: Fesoterodine has 11 (also Diltiazem, Warfarin, Fluconazole, Verapamil); Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine).
What mechanism field is on file for Fesoterodine and Estradiol?
Fesoterodine does not change the amount of estradiol in your blood, so the two drugs do not have a meaningful effect on each other.
Fesoterodine carries more major-labeled pairs than Estradiol
SPL source-record counts only. This page's band is minor · classes on file: Fesoterodine (Anticholinergic (Overactive Bladder)); Estradiol (Estrogen Hormone).
Fesoterodine has 2 major-labeled pairs vs Estradiol's 1. This page itself is in the minor band, not the major band.
2 major · 2 moderate · 11 minor · 15 total
- Other minor peers for Fesoterodine
- Diltiazem
- Warfarin
- Fluconazole
- Verapamil
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.