Fesoterodine and Clarithromycin Interaction
Drug interaction information between Fesoterodine and Clarithromycin.
Fesoterodine and Clarithromycin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fesoterodine and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin blocks the process your body uses to get rid of fesoterodine, causing the drug levels to rise.
FDA Label Information
7.2 CYP3A4 Inhibitors Doses of fesoterodine fumarate greater than 4 mg are not recommended in adult patients taking strong CYP3A4 inhibitors, such as ketoconazole, itraconazole, and clarithromycin [see Dosage and Administration (2.5) ] .
Fesoterodine Also Interacts With
- Darunavir major
- Itraconazole major
- Ketoconazole moderate
- Estradiol minor
- Diltiazem minor
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Fesoterodine + Clarithromycin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Fesoterodine's 15. In the moderate band specifically: Fesoterodine has 2 (also Ketoconazole); Clarithromycin has 35 (also Omeprazole, Methylprednisolone, Sildenafil, Valproate).
What mechanism field is on file for Fesoterodine and Clarithromycin?
Clarithromycin blocks the process your body uses to get rid of fesoterodine, causing the drug levels to rise.
Clarithromycin carries more major-labeled pairs than Fesoterodine
SPL source-record counts only. This page's band is moderate · classes on file: Fesoterodine (Anticholinergic (Overactive Bladder)); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Fesoterodine's 2. This page itself is in the moderate band, not the major band.
2 major · 2 moderate · 11 minor · 15 total
- Other moderate peers for Fesoterodine
- Ketoconazole
16 major · 35 moderate · 30 minor · 81 total
- Other moderate peers for Clarithromycin
- Omeprazole
- Methylprednisolone
- Sildenafil
- Valproate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.