What the FDA labels say about taking them together
Fesoterodine and fluconazole
Fesoterodine's FDA label of April 7, 2026 names fluconazole in its drug interactions section; the fluconazole labels PlainMeds reads (2) do not name fesoterodine. The fesoterodine label: “Following blockade of CYP3A4 by coadministration of the moderate CYP3A4 inhibitor fluconazole 200 mg twice a day for 2 days, the average (90% confidence interval) increase in C max and AUC of the active metabolite of …”
Check it at the source: the fesoterodine FDA label on DailyMed (effective April 7, 2026, Pfizer Laboratories Div Pfizer Inc); the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the fesoterodine label say about fluconazole?
Fesoterodine label, drug interactionsFollowing blockade of CYP3A4 by coadministration of the moderate CYP3A4 inhibitor fluconazole 200 mg twice a day for 2 days, the average (90% confidence interval) increase in C max and AUC of the active metabolite of fesoterodine was approximately 19% (11%–28%) and 27% (18%–36%) respectively.
Source: FDA drug label (Toviaz), Pfizer Laboratories Div Pfizer Inc, effective April 7, 2026 (SPL set 5be745f0-8ae7-4c3c-9962-37d6263326f1), via openFDA; the full label on DailyMed
What does the fluconazole label say about fesoterodine?
Fluconazole's label (effective April 7, 2026) and its 1 other brand-application label do not name fesoterodine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fesoterodine | Fluconazole | |
|---|---|---|
| Labeled for | Overactive bladder | Fungal infections, Urinary tract infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.794 per tablet 4 mg tablet | $0.380 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once