Fesoterodine and Fluconazole Interaction
Drug interaction information between Fesoterodine and Fluconazole.
Fesoterodine and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fesoterodine and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole slows down the process of clearing fesoterodine from your system, leading to a small increase in drug levels.
FDA Label Information
Following blockade of CYP3A4 by co-administration of the moderate CYP3A4 inhibitor fluconazole 200 mg twice a day for 2 days, the average (90% confidence interval) increase in C max and AUC of the active metabolite of fesoterodine was approximately 19% (11% to 28%) and 27% (18% to 36%) respectively. No dosing adjustments are recommended in the presence of moderate CYP3A4 inhibitors (e.g., erythromycin, fluconazole, diltiazem, verapamil and grapefruit juice).
Fesoterodine Also Interacts With
- Darunavir major
- Itraconazole major
- Ketoconazole moderate
- Clarithromycin moderate
- Estradiol minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Fesoterodine + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Fesoterodine's 15. In the minor band specifically: Fesoterodine has 11 (also Estradiol, Diltiazem, Warfarin, Verapamil); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Fesoterodine and Fluconazole?
Fluconazole slows down the process of clearing fesoterodine from your system, leading to a small increase in drug levels.
Fluconazole carries more major-labeled pairs than Fesoterodine
SPL source-record counts only. This page's band is minor · classes on file: Fesoterodine (Anticholinergic (Overactive Bladder)); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Fesoterodine's 2. This page itself is in the minor band, not the major band.
2 major · 2 moderate · 11 minor · 15 total
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.