Fesoterodine and Darunavir Interaction
Drug interaction information between Fesoterodine and Darunavir.
Fesoterodine and Darunavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Fesoterodine and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir interferes with the way your body clears fesoterodine, leading to higher levels of the medication in your blood.
FDA Label Information
Urinary antispasmodics fesoterodine ↑ fesoterodine When fesoterodine is co-administered with darunavir/ritonavir, do not exceed a fesoterodine dose of 4 mg once daily.
Fesoterodine Also Interacts With
- Itraconazole major
- Ketoconazole moderate
- Clarithromycin moderate
- Estradiol minor
- Diltiazem minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Fesoterodine + Darunavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Fesoterodine's 15. In the major band specifically: Fesoterodine has 2 (also Itraconazole); Darunavir has 15 (also Lovastatin, Sildenafil, Lurasidone, Pimozide).
What mechanism field is on file for Fesoterodine and Darunavir?
Darunavir interferes with the way your body clears fesoterodine, leading to higher levels of the medication in your blood.
Darunavir carries more major-labeled pairs than Fesoterodine
SPL source-record counts only. This page's band is major · classes on file: Fesoterodine (Anticholinergic (Overactive Bladder)); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Fesoterodine's 2.
2 major · 2 moderate · 11 minor · 15 total
- Other major peers for Fesoterodine
- Itraconazole
15 major · 16 moderate · 70 minor · 101 total
- Other major peers for Darunavir
- Lovastatin
- Sildenafil
- Lurasidone
- Pimozide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.