Etodolac and Furosemide Interaction
Drug interaction information between Etodolac and Furosemide.
Etodolac and Furosemide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Etodolac and Furosemide. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Etodolac can stop your water pill from removing salt and water effectively, which can cause your blood pressure to rise.
What To Do
Monitor your blood pressure closely and tell your doctor if you notice any swelling or weight gain.
FDA Label Information
Diuretics Etodolac has no apparent pharmacokinetic interaction when administered with furosemide or hydrochlorothiazide. Nevertheless, clinical studies, as well as postmarketing observations have shown that etodolac can reduce the natriuretic effect of furosemide and thiazides in some patients with possible loss of blood pressure control.
Etodolac Also Interacts With
- Warfarin moderate
- Hydrochlorothiazide minor
- Aspirin minor
- Methotrexate minor
- Cyclosporine minor
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Lithium moderate
Frequently Asked Questions
Can I take Etodolac and Furosemide together?
This is a minor interaction. Monitor your blood pressure closely and tell your doctor if you notice any swelling or weight gain.
How serious is the interaction between Etodolac and Furosemide?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Etodolac and Furosemide interact?
Etodolac can stop your water pill from removing salt and water effectively, which can cause your blood pressure to rise.
Understanding the Etodolac and Furosemide Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Etodolac belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class and Furosemide belongs to the Loop Diuretic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Etodolac can stop your water pill from removing salt and water effectively, which can cause your blood pressure to rise. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Etodolac has 10 total documented interactions on file in this dataset, and Furosemide has 36. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Monitor your blood pressure closely and tell your doctor if you notice any swelling or weight gain. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Etodolac or Furosemide based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.