Etodolac and Furosemide Interaction
Drug interaction information between Etodolac and Furosemide.
Etodolac and Furosemide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Etodolac and Furosemide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Etodolac can stop your water pill from removing salt and water effectively, which can cause your blood pressure to rise.
FDA Label Information
Diuretics Etodolac has no apparent pharmacokinetic interaction when administered with furosemide or hydrochlorothiazide. Nevertheless, clinical studies, as well as postmarketing observations have shown that etodolac can reduce the natriuretic effect of furosemide and thiazides in some patients with possible loss of blood pressure control.
Etodolac Also Interacts With
- Warfarin moderate
- Hydrochlorothiazide minor
- Aspirin minor
- Methotrexate minor
- Cyclosporine minor
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Etodolac + Furosemide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Furosemide has 36 labeled pairs on file vs Etodolac's 10. In the minor band specifically: Etodolac has 9 (also Hydrochlorothiazide, Aspirin, Methotrexate, Cyclosporine); Furosemide has 29 (also Methotrexate, Norepinephrine, Ethacrynic Acid, Indomethacin).
What mechanism field is on file for Etodolac and Furosemide?
Etodolac can stop your water pill from removing salt and water effectively, which can cause your blood pressure to rise.
Furosemide carries more major-labeled pairs than Etodolac
SPL source-record counts only. This page's band is minor · classes on file: Etodolac (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Furosemide (Loop Diuretic).
Furosemide has 3 major-labeled pairs vs Etodolac's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 9 minor · 10 total
- Other minor peers for Etodolac
- Hydrochlorothiazide
- Aspirin
- Methotrexate
- Cyclosporine
3 major · 4 moderate · 29 minor · 36 total
- Other minor peers for Furosemide
- Methotrexate
- Norepinephrine
- Ethacrynic Acid
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.