Etodolac and Aspirin Interaction
Drug interaction information between Etodolac and Aspirin.
Etodolac and Aspirin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Etodolac and Aspirin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Taking these together changes how the medicine travels through your blood and increases the chance of harmful side effects.
What To Do
This combination is generally not recommended, so talk to your doctor about safer alternatives for pain relief.
FDA Label Information
Aspirin When etodolac is administered with aspirin, its protein binding is reduced, although the clearance of free etodolac is not altered. The clinical significance of this interaction is not known; however, as with other NSAIDs, concomitant administration of etodolac and aspirin is not generally recommended because of the potential of increased adverse effects.
Etodolac Also Interacts With
- Warfarin moderate
- Hydrochlorothiazide minor
- Furosemide minor
- Methotrexate minor
- Cyclosporine minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
Can I take Etodolac and Aspirin together?
This is a minor interaction. This combination is generally not recommended, so talk to your doctor about safer alternatives for pain relief.
How serious is the interaction between Etodolac and Aspirin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Etodolac and Aspirin interact?
Taking these together changes how the medicine travels through your blood and increases the chance of harmful side effects.
Understanding the Etodolac and Aspirin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Etodolac belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class and Aspirin belongs to the Antiplatelet / NSAID class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Taking these together changes how the medicine travels through your blood and increases the chance of harmful side effects. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Etodolac has 10 total documented interactions on file in this dataset, and Aspirin has 47. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: This combination is generally not recommended, so talk to your doctor about safer alternatives for pain relief. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Etodolac or Aspirin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.