What the FDA labels say about taking them together
Aspirin and etodolac
Etodolac's FDA label of July 16, 2026 names aspirin in its contraindications section; aspirin's label does not name etodolac itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The etodolac label: “Aspirin When etodolac is administered with aspirin, its protein binding is reduced, although the clearance of free etodolac is not altered.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the etodolac FDA label on DailyMed (effective July 16, 2026, Aurobindo Pharma Limited).
What does the aspirin label say about etodolac?
Aspirin's label does not name etodolac itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Aspirin label, warningsThis product contains an NSAID, which may cause severe stomach bleeding.
Aspirin label, warningsThe chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcohol drinks every day while using this product take more or for a longer time than directed
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the etodolac label say about aspirin?
Etodolac label, contraindicationsEtodolac tablets should not be given to patients who have experienced asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
Etodolac label, drug interactionsAspirin When etodolac is administered with aspirin, its protein binding is reduced, although the clearance of free etodolac is not altered.
Etodolac label, warningsThere is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use.
Source: FDA drug label (Etodolac), Aurobindo Pharma Limited, effective July 16, 2026 (SPL set c74c3c56-a5ac-40b4-974b-c4f4b05c5df9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Etodolac | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Pain, Osteoarthritis, Rheumatoid arthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.262 per tablet 400 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once