Etodolac and Aspirin Interaction
Drug interaction information between Etodolac and Aspirin.
Etodolac and Aspirin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Etodolac and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these together changes how the medicine travels through your blood and increases the chance of harmful side effects.
FDA Label Information
Aspirin When etodolac is administered with aspirin, its protein binding is reduced, although the clearance of free etodolac is not altered. The clinical significance of this interaction is not known; however, as with other NSAIDs, concomitant administration of etodolac and aspirin is not generally recommended because of the potential of increased adverse effects.
Etodolac Also Interacts With
- Warfarin moderate
- Hydrochlorothiazide minor
- Furosemide minor
- Methotrexate minor
- Cyclosporine minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Etodolac + Aspirin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Etodolac's 10. In the minor band specifically: Etodolac has 9 (also Hydrochlorothiazide, Furosemide, Methotrexate, Cyclosporine); Aspirin has 32 (also Carisoprodol, Celecoxib, Colestipol, Diflunisal).
What mechanism field is on file for Etodolac and Aspirin?
Taking these together changes how the medicine travels through your blood and increases the chance of harmful side effects.
Aspirin carries more major-labeled pairs than Etodolac
SPL source-record counts only. This page's band is minor · classes on file: Etodolac (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Aspirin (Antiplatelet / NSAID).
Aspirin has 3 major-labeled pairs vs Etodolac's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 9 minor · 10 total
- Other minor peers for Etodolac
- Hydrochlorothiazide
- Furosemide
- Methotrexate
- Cyclosporine
3 major · 12 moderate · 32 minor · 47 total
- Other minor peers for Aspirin
- Carisoprodol
- Celecoxib
- Colestipol
- Diflunisal
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.