Etodolac and Warfarin Interaction
Drug interaction information between Etodolac and Warfarin.
Etodolac and Warfarin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Etodolac and Warfarin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both drugs increase the risk of bleeding, and taking them together makes a serious stomach bleed much more likely. Etodolac also changes how warfarin travels through the bloodstream.
What To Do
Be very careful when taking these drugs together and watch for signs of unusual bruising or bleeding. Your doctor may need to check your blood more often.
FDA Label Information
Warfarin The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than that of users of either drug alone. Short-term pharmacokinetic studies have demonstrated that concomitant administration of warfarin and etodolac results in reduced protein binding of warfarin, but there was no change in the clearance of free warfarin. There was no significant difference in the pharmacodynamic effect of warfarin administered alone and warfarin administered with etodolac as measured by prothrombin time.
Etodolac Also Interacts With
- Hydrochlorothiazide minor
- Furosemide minor
- Aspirin minor
- Methotrexate minor
- Cyclosporine minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
Can I take Etodolac and Warfarin together?
This is a moderate interaction. Be very careful when taking these drugs together and watch for signs of unusual bruising or bleeding. Your doctor may need to check your blood more often.
How serious is the interaction between Etodolac and Warfarin?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Etodolac and Warfarin interact?
Both drugs increase the risk of bleeding, and taking them together makes a serious stomach bleed much more likely. Etodolac also changes how warfarin travels through the bloodstream.
Understanding the Etodolac and Warfarin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Etodolac belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class and Warfarin belongs to the Vitamin K Antagonist (Anticoagulant) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both drugs increase the risk of bleeding, and taking them together makes a serious stomach bleed much more likely. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Etodolac has 10 total documented interactions on file in this dataset, and Warfarin has 163. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Be very careful when taking these drugs together and watch for signs of unusual bruising or bleeding. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Etodolac or Warfarin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.