Etodolac and Warfarin Interaction
Drug interaction information between Etodolac and Warfarin.
Etodolac and Warfarin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Etodolac and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs increase the risk of bleeding, and taking them together makes a serious stomach bleed much more likely. Etodolac also changes how warfarin travels through the bloodstream.
FDA Label Information
Warfarin The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than that of users of either drug alone. Short-term pharmacokinetic studies have demonstrated that concomitant administration of warfarin and etodolac results in reduced protein binding of warfarin, but there was no change in the clearance of free warfarin. There was no significant difference in the pharmacodynamic effect of warfarin administered alone and warfarin administered with etodolac as measured by prothrombin time.
Etodolac Also Interacts With
- Hydrochlorothiazide minor
- Furosemide minor
- Aspirin minor
- Methotrexate minor
- Cyclosporine minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Etodolac + Warfarin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Etodolac's 10. In the moderate band specifically: Etodolac has 1; Warfarin has 28 (also Ibuprofen, Aspirin, Diclofenac, Desvenlafaxine).
What mechanism field is on file for Etodolac and Warfarin?
Both drugs increase the risk of bleeding, and taking them together makes a serious stomach bleed much more likely. Etodolac also changes how warfarin travels through the bloodstream.
Warfarin carries more major-labeled pairs than Etodolac
SPL source-record counts only. This page's band is moderate · classes on file: Etodolac (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Etodolac's 0. This page itself is in the moderate band, not the major band.
0 major · 1 moderate · 9 minor · 10 total
Etodolac has no other moderate-band peer in this dataset besides Warfarin.
2 major · 28 moderate · 133 minor · 163 total
- Other moderate peers for Warfarin
- Ibuprofen
- Aspirin
- Diclofenac
- Desvenlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.