etodolac vs furosemide
Side-by-side comparison of etodolac and furosemide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Diuretics Etodolac has no apparent pharmacokinetic interaction when administered with furosemide or hydrochlorothiazide. Nevertheless, clinical studies, as well as postmarketing observations have shown that etodolac can reduce the natriuretic effect of furosemide and thiazides in some patients with possible loss of blood pressure control.
Recommendation: Monitor your blood pressure closely and tell your doctor if you notice any swelling or weight gain.
Lodine
Lasix
Etodolac is a pain reliever and anti-inflammatory medicine. It helps reduce pain, swelling, and stiffness caused by arthritis and other conditions.
Furosemide is a water pill (diuretic). It helps your body get rid of extra water and salt.
Etodolac treats the symptoms of osteoarthritis and rheumatoid arthritis. It can help with pain and swelling in your joints. Etodolac is also used for short-term relief of acute pain.
This medicine treats swelling (edema) from heart failure, liver problems, or kidney disease. It can also treat high blood pressure. Furosemide is helpful when you need a stronger diuretic.
Etodolac is an NSAID, which stands for Nonsteroidal Anti-Inflammatory Drug. It works by reducing substances in the body that cause pain and inflammation. It can help to reduce fever as well.
Furosemide works in your kidneys. It helps your kidneys remove more salt and water from your blood. This lowers the amount of fluid in your body and lowers blood pressure.
- • Upset stomach
- • Constipation
- • Diarrhea
- • Gas
- • Heartburn
- • Dizziness
- • Headache
- • Blurred vision
- • Nausea
- • Vomiting
- Pain 350
- Feeling sick to your stomach 290
- Joint pain 284
- Tiredness 273
- Headache 239
- Difficulty breathing 29,099
- Tiredness 20,389
- Diarrhea 19,940
- Feeling sick to your stomach 18,682
- Sudden kidney damage 18,530
NSAIDs like etodolac can increase your risk of heart attack or stroke, which can be fatal. This risk may happen early in treatment and increases with longer use. You should not take etodolac if you are having heart bypass surgery. NSAIDs also increase the risk of serious stomach problems like bleeding and ulcers, which can be fatal. Older adults are at higher risk for these stomach problems.
Furosemide can cause you to lose too much fluid and electrolytes. This can lead to dehydration, low blood pressure, and kidney problems. Your doctor should check your blood regularly while you are taking this medicine.
Talk to your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. Etodolac may harm your unborn baby. It is not known if etodolac passes into breast milk.
Tell your doctor if you are pregnant or plan to become pregnant. Furosemide may not be safe during pregnancy. Talk to your doctor about the risks and benefits of taking this medicine while breastfeeding.
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How to Read This etodolac vs furosemide Comparison
etodolac is classified in the Nonsteroidal Anti-Inflammatory Drug (NSAID) drug class, while furosemide sits within the Loop Diuretic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, etodolac has 1,436 submissions while furosemide has 106,640. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to etodolac can stop your water pill from removing salt and water effectively, which can cause your blood pressure to rise.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between etodolac and furosemide - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.