Etodolac and Hydrochlorothiazide Interaction
Drug interaction information between Etodolac and Hydrochlorothiazide.
Etodolac and Hydrochlorothiazide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Etodolac and Hydrochlorothiazide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs do not significantly change how the body absorbs or processes each other.
FDA Label Information
Diuretics Etodolac has no apparent pharmacokinetic interaction when administered with furosemide or hydrochlorothiazide.
Etodolac Also Interacts With
- Warfarin moderate
- Furosemide minor
- Aspirin minor
- Methotrexate minor
- Cyclosporine minor
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Hydrochlorothiazide/Triamterene major
- Lisinopril major
- Olmesartan moderate
- Losartan minor
Frequently Asked Questions
What SPL severity band is on file for Etodolac + Hydrochlorothiazide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Hydrochlorothiazide has 31 labeled pairs on file vs Etodolac's 10. In the minor band specifically: Etodolac has 9 (also Furosemide, Aspirin, Methotrexate, Cyclosporine); Hydrochlorothiazide has 27 (also Losartan, Spironolactone, Propranolol, Lithium).
What mechanism field is on file for Etodolac and Hydrochlorothiazide?
These drugs do not significantly change how the body absorbs or processes each other.
Hydrochlorothiazide carries more major-labeled pairs than Etodolac
SPL source-record counts only. This page's band is minor · classes on file: Etodolac (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Hydrochlorothiazide (Thiazide Diuretic).
Hydrochlorothiazide has 3 major-labeled pairs vs Etodolac's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 9 minor · 10 total
- Other minor peers for Etodolac
- Furosemide
- Aspirin
- Methotrexate
- Cyclosporine
3 major · 1 moderate · 27 minor · 31 total
- Other minor peers for Hydrochlorothiazide
- Losartan
- Spironolactone
- Propranolol
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.