Etodolac and Cyclosporine Interaction
Drug interaction information between Etodolac and Cyclosporine.
Etodolac and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Etodolac and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Etodolac makes it harder for your kidneys to remove cyclosporine from your blood, which can lead to toxic levels. This combination can also increase the risk of damage to your kidneys.
FDA Label Information
Cyclosporine, Digoxin, Methotrexate Etodolac, like other NSAIDs, through effects on renal prostaglandins, may cause changes in the elimination of these drugs leading to elevated serum levels of cyclosporine, digoxin, methotrexate, and increased toxicity. Nephrotoxicity associated with cyclosporine may also be enhanced.
Etodolac Also Interacts With
- Warfarin moderate
- Hydrochlorothiazide minor
- Furosemide minor
- Aspirin minor
- Methotrexate minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Etodolac + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Etodolac's 10. In the minor band specifically: Etodolac has 9 (also Hydrochlorothiazide, Furosemide, Aspirin, Methotrexate); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Etodolac and Cyclosporine?
Etodolac makes it harder for your kidneys to remove cyclosporine from your blood, which can lead to toxic levels. This combination can also increase the risk of damage to your kidneys.
Cyclosporine carries more major-labeled pairs than Etodolac
SPL source-record counts only. This page's band is minor · classes on file: Etodolac (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Etodolac's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 9 minor · 10 total
- Other minor peers for Etodolac
- Hydrochlorothiazide
- Furosemide
- Aspirin
- Methotrexate
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.