Ertugliflozin and Ranolazine Interaction
Drug interaction information between Ertugliflozin and Ranolazine.
Ertugliflozin and Ranolazine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ertugliflozin and Ranolazine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Ranolazine prevents the kidneys from properly filtering metformin out of the blood, which can lead to a higher amount of metformin in your system.
What To Do
You and your doctor should discuss the risks of this combination and monitor for any signs of metformin toxicity.
FDA Label Information
Drugs that Reduce Metformin Clearance Clinical Impact: The risk of lactic acidosis may increase due to concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT2] / multidrug and toxin extrusion [MATE] inhibitors such as ranolazine, vandetanib, dolutegravir, and cimetidine) which increase systemic exposure to metformin Intervention Consider the benefits and risks of concomitant use.
Ertugliflozin Also Interacts With
- Metformin moderate
- Topiramate moderate
- Dolutegravir moderate
- Cimetidine moderate
- Zonisamide moderate
Ranolazine Also Interacts With
- Ketoconazole major
- Carbamazepine major
- Clarithromycin major
- Rifampin major
- Phenytoin major
Frequently Asked Questions
Can I take Ertugliflozin and Ranolazine together?
This is a moderate interaction. You and your doctor should discuss the risks of this combination and monitor for any signs of metformin toxicity.
How serious is the interaction between Ertugliflozin and Ranolazine?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Ertugliflozin and Ranolazine interact?
Ranolazine prevents the kidneys from properly filtering metformin out of the blood, which can lead to a higher amount of metformin in your system.
Understanding the Ertugliflozin and Ranolazine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Ertugliflozin belongs to the SGLT2 Inhibitor class and Ranolazine belongs to the Late Sodium Current Inhibitor (Antianginal) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Ranolazine prevents the kidneys from properly filtering metformin out of the blood, which can lead to a higher amount of metformin in your system. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Ertugliflozin has 8 total documented interactions on file in this dataset, and Ranolazine has 31. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You and your doctor should discuss the risks of this combination and monitor for any signs of metformin toxicity. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Ertugliflozin or Ranolazine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.