Ertugliflozin and Ranolazine Interaction
Drug interaction information between Ertugliflozin and Ranolazine.
Ertugliflozin and Ranolazine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ertugliflozin and Ranolazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ranolazine prevents the kidneys from properly filtering metformin out of the blood, which can lead to a higher amount of metformin in your system.
FDA Label Information
Drugs that Reduce Metformin Clearance Clinical Impact: The risk of lactic acidosis may increase due to concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT2] / multidrug and toxin extrusion [MATE] inhibitors such as ranolazine, vandetanib, dolutegravir, and cimetidine) which increase systemic exposure to metformin Intervention Consider the benefits and risks of concomitant use.
Ertugliflozin Also Interacts With
- Metformin moderate
- Topiramate moderate
- Dolutegravir moderate
- Cimetidine moderate
- Zonisamide moderate
Ranolazine Also Interacts With
- Ketoconazole major
- Carbamazepine major
- Clarithromycin major
- Rifampin major
- Phenytoin major
Frequently Asked Questions
What SPL severity band is on file for Ertugliflozin + Ranolazine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ranolazine has 31 labeled pairs on file vs Ertugliflozin's 8. In the moderate band specifically: Ertugliflozin has 6 (also Metformin, Topiramate, Dolutegravir, Cimetidine); Ranolazine has 7 (also Empagliflozin, Empagliflozin/Linagliptin, Linagliptin, Lovastatin).
What mechanism field is on file for Ertugliflozin and Ranolazine?
Ranolazine prevents the kidneys from properly filtering metformin out of the blood, which can lead to a higher amount of metformin in your system.
Ranolazine carries more major-labeled pairs than Ertugliflozin
SPL source-record counts only. This page's band is moderate · classes on file: Ertugliflozin (SGLT2 Inhibitor); Ranolazine (Late Sodium Current Inhibitor (Antianginal)).
Ranolazine has 12 major-labeled pairs vs Ertugliflozin's 0. This page itself is in the moderate band, not the major band.
0 major · 6 moderate · 2 minor · 8 total
- Other moderate peers for Ertugliflozin
- Metformin
- Topiramate
- Dolutegravir
- Cimetidine
12 major · 7 moderate · 12 minor · 31 total
- Other moderate peers for Ranolazine
- Empagliflozin
- Empagliflozin/Linagliptin
- Linagliptin
- Lovastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.