Eluxadoline and Alosetron Interaction
Drug interaction information between Eluxadoline and Alosetron.
Eluxadoline and Alosetron have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Eluxadoline and Alosetron. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Eluxadoline can interfere with how your body breaks down alosetron, leading to higher amounts of alosetron in your bloodstream.
What To Do
Your healthcare provider should monitor you for increased side effects when these two drugs are used at the same time.
FDA Label Information
Examples: alosetron, anticholinergics, opioids Table 3: Established and Other Potentially Clinically Relevant Interactions Affecting Drugs Co-Administered with VIBERZI OATP1B1 and BCRP Substrate Clinical Impact: VIBERZI may increase the exposure of co-administered OATP1B1 and BCRP substrates.
Eluxadoline Also Interacts With
- Rosuvastatin moderate
- Rifampin moderate
- Loperamide moderate
- Gemfibrozil moderate
- Cyclosporine minor
Alosetron Also Interacts With
- Clarithromycin moderate
- Itraconazole moderate
- Voriconazole moderate
- Estradiol minor
- Hydralazine minor
Frequently Asked Questions
Can I take Eluxadoline and Alosetron together?
This is a minor interaction. Your healthcare provider should monitor you for increased side effects when these two drugs are used at the same time.
How serious is the interaction between Eluxadoline and Alosetron?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Eluxadoline and Alosetron interact?
Eluxadoline can interfere with how your body breaks down alosetron, leading to higher amounts of alosetron in your bloodstream.
Understanding the Eluxadoline and Alosetron Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Eluxadoline belongs to the Mu-Opioid Receptor Agonist (IBS-D) class and Alosetron belongs to the 5-HT3 Antagonist (IBS-D) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Eluxadoline can interfere with how your body breaks down alosetron, leading to higher amounts of alosetron in your bloodstream. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Eluxadoline has 6 total documented interactions on file in this dataset, and Alosetron has 12. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your healthcare provider should monitor you for increased side effects when these two drugs are used at the same time. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Eluxadoline or Alosetron based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.