Eluxadoline and Alosetron Interaction
Drug interaction information between Eluxadoline and Alosetron.
Eluxadoline and Alosetron have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Eluxadoline and Alosetron. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Eluxadoline can interfere with how your body breaks down alosetron, leading to higher amounts of alosetron in your bloodstream.
FDA Label Information
Examples: alosetron, anticholinergics, opioids Table 3: Established and Other Potentially Clinically Relevant Interactions Affecting Drugs Co-Administered with VIBERZI OATP1B1 and BCRP Substrate Clinical Impact: VIBERZI may increase the exposure of co-administered OATP1B1 and BCRP substrates.
Eluxadoline Also Interacts With
- Rosuvastatin moderate
- Rifampin moderate
- Loperamide moderate
- Gemfibrozil moderate
- Cyclosporine minor
Alosetron Also Interacts With
- Clarithromycin moderate
- Itraconazole moderate
- Voriconazole moderate
- Estradiol minor
- Hydralazine minor
Frequently Asked Questions
What SPL severity band is on file for Eluxadoline + Alosetron?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Alosetron has 12 labeled pairs on file vs Eluxadoline's 6. In the minor band specifically: Eluxadoline has 2 (also Cyclosporine); Alosetron has 9 (also Estradiol, Hydralazine, Ketoconazole, Theophylline).
What mechanism field is on file for Eluxadoline and Alosetron?
Eluxadoline can interfere with how your body breaks down alosetron, leading to higher amounts of alosetron in your bloodstream.
Alosetron's labeled portfolio outnumbers Eluxadoline
SPL source-record counts only. This page's band is minor · classes on file: Eluxadoline (Mu-Opioid Receptor Agonist (IBS-D)); Alosetron (5-HT3 Antagonist (IBS-D)).
0 major · 3 moderate · 9 minor · 12 total
- Other minor peers for Alosetron
- Estradiol
- Hydralazine
- Ketoconazole
- Theophylline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.