What the FDA labels say about taking them together
Alosetron and eluxadoline
Eluxadoline's FDA label of July 16, 2024 names alosetron in its drug interactions section; the alosetron label PlainMeds reads does not name eluxadoline. The eluxadoline label: “Increased risk for constipation related adverse reactions and potential for constipation related serious adverse reactions”
Check it at the source: the alosetron FDA label on DailyMed (effective March 23, 2026, Legacy Pharma USA Inc.); the eluxadoline FDA label on DailyMed (effective July 16, 2024, Allergan, Inc.).
What does the alosetron label say about eluxadoline?
Alosetron's label (effective March 23, 2026) does not name eluxadoline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LOTRONEX), Legacy Pharma USA Inc., effective March 23, 2026 (SPL set c216e967-436f-475a-8e6a-2ad11adc63af), via openFDA; the full label on DailyMed
What does the eluxadoline label say about alosetron?
Eluxadoline label, drug interactionsDrugs that Cause Constipation Clinical Impact: Increased risk for constipation related adverse reactions and potential for constipation related serious adverse reactions Intervention: Avoid use with other drugs that may cause constipation (see below); loperamide may be used occasionally for acute management of severe diarrhea but avoid chronic use. Discontinue loperamide immediately if constipation occurs. Examples: alosetron, anticholinergics, opioids
Source: FDA drug label (Viberzi), NDA206940 (Abbvie), as published by Allergan, Inc., effective July 16, 2024 (SPL set 7821bd40-4c84-4984-951b-6436ae20421a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alosetron | Eluxadoline | |
|---|---|---|
| Labeled for | n/a | Irritable bowel syndrome, Diarrhea |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $2.02 per tablet 0.5 mg tablet | $28.09 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once