What the FDA labels say about taking them together
Eluxadoline and loperamide
Eluxadoline's FDA label of July 16, 2024 names loperamide in its drug interactions section; the loperamide label PlainMeds reads does not name eluxadoline. The eluxadoline label: “Increased risk for constipation related adverse reactions and potential for constipation related serious adverse reactions”
Check it at the source: the eluxadoline FDA label on DailyMed (effective July 16, 2024, Allergan, Inc.); the loperamide FDA label on DailyMed (effective June 3, 2026, Aurobindo Pharma Limited).
What does the eluxadoline label say about loperamide?
Eluxadoline label, drug interactionsDrugs that Cause Constipation Clinical Impact: Increased risk for constipation related adverse reactions and potential for constipation related serious adverse reactions Intervention: Avoid use with other drugs that may cause constipation (see below); loperamide may be used occasionally for acute management of severe diarrhea but avoid chronic use. Discontinue loperamide immediately if constipation occurs. Examples: alosetron, anticholinergics, opioids
Source: FDA drug label (Viberzi), NDA206940 (Abbvie), as published by Allergan, Inc., effective July 16, 2024 (SPL set 7821bd40-4c84-4984-951b-6436ae20421a), via openFDA; the full label on DailyMed
What does the loperamide label say about eluxadoline?
Loperamide's label (effective June 3, 2026) does not name eluxadoline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Loperamide Hydrochloride), Aurobindo Pharma Limited, effective June 3, 2026 (SPL set 8e4004be-bf79-4631-9e38-c4e7b6726313), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Eluxadoline | Loperamide | |
|---|---|---|
| Labeled for | Irritable bowel syndrome, Diarrhea | Diarrhea |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $28.09 per tablet 100 mg tablet | $0.0549 per capsule 2 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once