Eluxadoline and Loperamide Interaction
Drug interaction information between Eluxadoline and Loperamide.
Eluxadoline and Loperamide have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Eluxadoline and Loperamide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medicines both work to slow down your bowels, and using them together can cause dangerous levels of constipation.
FDA Label Information
Examples: cyclosporine, gemfibrozil, antiretrovirals (atazanavir, lopinavir, ritonavir, saquinavir, tipranavir), rifampin, eltrombopag Drugs that Cause Constipation Clinical Impact: Increased risk for constipation related adverse reactions and potential for constipation related serious adverse reactions Intervention: Avoid use with other drugs that may cause constipation (see below); loperamide may be used occasionally for acute management of severe diarrhea but avoid chronic use. Discontinue loperamide immediately if constipation occurs.
Eluxadoline Also Interacts With
- Rosuvastatin moderate
- Rifampin moderate
- Gemfibrozil moderate
- Cyclosporine minor
- Alosetron minor
Frequently Asked Questions
What SPL severity band is on file for Eluxadoline + Loperamide?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Eluxadoline has 6 labeled pairs on file vs Loperamide's 2. In the moderate band specifically: Eluxadoline has 4 (also Rosuvastatin, Rifampin, Gemfibrozil); Loperamide has 1.
What mechanism field is on file for Eluxadoline and Loperamide?
These medicines both work to slow down your bowels, and using them together can cause dangerous levels of constipation.
Eluxadoline's labeled portfolio outnumbers Loperamide
SPL source-record counts only. This page's band is moderate · classes on file: Eluxadoline (Mu-Opioid Receptor Agonist (IBS-D)); Loperamide (Antidiarrheal (Opioid Receptor Agonist)).
0 major · 4 moderate · 2 minor · 6 total
- Other moderate peers for Eluxadoline
- Rosuvastatin
- Rifampin
- Gemfibrozil
0 major · 1 moderate · 1 minor · 2 total
Loperamide has no other moderate-band peer in this dataset besides Eluxadoline.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.