Eluxadoline and Rifampin Interaction
Drug interaction information between Eluxadoline and Rifampin.
Eluxadoline and Rifampin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Eluxadoline and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications can slow down your digestive tract, which increases the risk of severe constipation.
FDA Label Information
Examples: cyclosporine, gemfibrozil, antiretrovirals (atazanavir, lopinavir, ritonavir, saquinavir, tipranavir), rifampin, eltrombopag Drugs that Cause Constipation Clinical Impact: Increased risk for constipation related adverse reactions and potential for constipation related serious adverse reactions Intervention: Avoid use with other drugs that may cause constipation (see below); loperamide may be used occasionally for acute management of severe diarrhea but avoid chronic use.
Eluxadoline Also Interacts With
- Rosuvastatin moderate
- Loperamide moderate
- Gemfibrozil moderate
- Cyclosporine minor
- Alosetron minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Eluxadoline + Rifampin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Eluxadoline's 6. In the moderate band specifically: Eluxadoline has 4 (also Rosuvastatin, Loperamide, Gemfibrozil); Rifampin has 26 (also Doxycycline, Probenecid, Theophylline, Apixaban).
What mechanism field is on file for Eluxadoline and Rifampin?
Both of these medications can slow down your digestive tract, which increases the risk of severe constipation.
Rifampin carries more major-labeled pairs than Eluxadoline
SPL source-record counts only. This page's band is moderate · classes on file: Eluxadoline (Mu-Opioid Receptor Agonist (IBS-D)); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Eluxadoline's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 2 minor · 6 total
- Other moderate peers for Eluxadoline
- Rosuvastatin
- Loperamide
- Gemfibrozil
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Probenecid
- Theophylline
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.