What the FDA labels say about taking them together
Eluxadoline and rifampin
Eluxadoline's FDA label of July 16, 2024 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name eluxadoline. The eluxadoline label: “Increased exposure to eluxadoline when coadministered with cyclosporine [ see Clinical Pharmacology () ]”
Check it at the source: the eluxadoline FDA label on DailyMed (effective July 16, 2024, Allergan, Inc.); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the eluxadoline label say about rifampin?
Eluxadoline label, drug interactionsOATP1B1 Inhibitors Clinical Impact: Increased exposure to eluxadoline when coadministered with cyclosporine [ see Clinical Pharmacology () ] … cyclosporine, gemfibrozil, antiretrovirals (atazanavir, lopinavir, ritonavir, saquinavir, tipranavir), rifampin, eltrombopag
Source: FDA drug label (Viberzi), NDA206940 (Abbvie), as published by Allergan, Inc., effective July 16, 2024 (SPL set 7821bd40-4c84-4984-951b-6436ae20421a), via openFDA; the full label on DailyMed
What does the rifampin label say about eluxadoline?
Rifampin's label (effective February 11, 2026) does not name eluxadoline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Eluxadoline | Rifampin | |
|---|---|---|
| Labeled for | Irritable bowel syndrome, Diarrhea | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $28.09 per tablet 100 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once