Eluxadoline and Rosuvastatin Interaction
Drug interaction information between Eluxadoline and Rosuvastatin.
Eluxadoline and Rosuvastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Eluxadoline and Rosuvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Eluxadoline can increase the amount of rosuvastatin in your blood, which may lead to a higher risk of muscle damage.
FDA Label Information
Increased exposure to rosuvastatin when co-administered with VIBERZI with a potential for increased risk of myopathy/rhabdomyolysis [ see Clinical Pharmacology ( 12.3 ) ] Intervention: Use the lowest effective dose of rosuvastatin (see prescribing information of rosuvastatin for additional information on recommended dosing).
Eluxadoline Also Interacts With
- Rifampin moderate
- Loperamide moderate
- Gemfibrozil moderate
- Cyclosporine minor
- Alosetron minor
Rosuvastatin Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
Frequently Asked Questions
What SPL severity band is on file for Eluxadoline + Rosuvastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rosuvastatin has 21 labeled pairs on file vs Eluxadoline's 6. In the moderate band specifically: Eluxadoline has 4 (also Rifampin, Loperamide, Gemfibrozil); Rosuvastatin has 8 (also Cyclosporine, Ledipasvir/Sofosbuvir, Colchicine, Gemfibrozil).
What mechanism field is on file for Eluxadoline and Rosuvastatin?
Eluxadoline can increase the amount of rosuvastatin in your blood, which may lead to a higher risk of muscle damage.
Rosuvastatin carries more major-labeled pairs than Eluxadoline
SPL source-record counts only. This page's band is moderate · classes on file: Eluxadoline (Mu-Opioid Receptor Agonist (IBS-D)); Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Rosuvastatin has 3 major-labeled pairs vs Eluxadoline's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 2 minor · 6 total
- Other moderate peers for Eluxadoline
- Rifampin
- Loperamide
- Gemfibrozil
3 major · 8 moderate · 10 minor · 21 total
- Other moderate peers for Rosuvastatin
- Cyclosporine
- Ledipasvir/Sofosbuvir
- Colchicine
- Gemfibrozil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.