What the FDA labels say about taking them together
Cyclosporine and eluxadoline
Eluxadoline's FDA label of July 16, 2024 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name eluxadoline. The eluxadoline label: “Increased exposure to eluxadoline when coadministered with cyclosporine [ see Clinical Pharmacology () ]”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the eluxadoline FDA label on DailyMed (effective July 16, 2024, Allergan, Inc.).
What does the cyclosporine label say about eluxadoline?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name eluxadoline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the eluxadoline label say about cyclosporine?
Eluxadoline label, drug interactionsOATP1B1 Inhibitors Clinical Impact: Increased exposure to eluxadoline when coadministered with cyclosporine [ see Clinical Pharmacology () ] … operating machinery and for other eluxadoline-related adverse reactions [see Adverse Reactions ()]. Examples: cyclosporine, gemfibrozil, antiretrovirals (atazanavir, lopinavir, ritonavir, saquinavir, tipranavir), rifampin, eltrombopag
Source: FDA drug label (Viberzi), NDA206940 (Abbvie), as published by Allergan, Inc., effective July 16, 2024 (SPL set 7821bd40-4c84-4984-951b-6436ae20421a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Eluxadoline | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Irritable bowel syndrome, Diarrhea |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $28.09 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once