Eluxadoline and Cyclosporine Interaction
Drug interaction information between Eluxadoline and Cyclosporine.
Eluxadoline and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Eluxadoline and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cyclosporine blocks a specific protein that helps remove eluxadoline from your system, which causes eluxadoline levels to rise in your body.
Eluxadoline Also Interacts With
- Rosuvastatin moderate
- Rifampin moderate
- Loperamide moderate
- Gemfibrozil moderate
- Alosetron minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Eluxadoline + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Eluxadoline's 6. In the minor band specifically: Eluxadoline has 2 (also Alosetron); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Eluxadoline and Cyclosporine?
Cyclosporine blocks a specific protein that helps remove eluxadoline from your system, which causes eluxadoline levels to rise in your body.
Cyclosporine carries more major-labeled pairs than Eluxadoline
SPL source-record counts only. This page's band is minor · classes on file: Eluxadoline (Mu-Opioid Receptor Agonist (IBS-D)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Eluxadoline's 0. This page itself is in the minor band, not the major band.
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.