Drospirenone and Tizanidine Interaction
Drug interaction information between Drospirenone and Tizanidine.
Drospirenone and Tizanidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Drospirenone and Tizanidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
The birth control pill interferes with the way your body clears tizanidine from your system. This can lead to higher levels of the drug in your body, which may increase side effects.
FDA Label Information
COCs Increasing the Plasma Concentrations of CYP450 Enzymes In clinical studies, administration of a hormonal contraceptive containing EE did not lead to any increase or only to a weak increase in plasma concentrations of CYP3A4 substrates (e.g., midazolam) while plasma concentrations of CYP2C19 substrates (e.g., omeprazole and voriconazole) and CYP1A2 substrates (e.g., theophylline and tizanidine) can have a weak or moderate increase.
Drospirenone Also Interacts With
- Estradiol major
- Atorvastatin minor
- Omeprazole minor
- Lamotrigine minor
- Topiramate minor
Tizanidine Also Interacts With
- Ciprofloxacin major
- Fluvoxamine major
- Famotidine moderate
- Acyclovir minor
- Verapamil minor
Frequently Asked Questions
What SPL severity band is on file for Drospirenone/Ethinyl Estradiol + Tizanidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Drospirenone has 30 labeled pairs on file vs Tizanidine's 17. In the minor band specifically: Drospirenone has 29 (also Atorvastatin, Omeprazole, Lamotrigine, Topiramate); Tizanidine has 14 (also Acyclovir, Verapamil, Amiodarone, Propafenone).
What mechanism field is on file for Drospirenone/Ethinyl Estradiol and Tizanidine?
The birth control pill interferes with the way your body clears tizanidine from your system. This can lead to higher levels of the drug in your body, which may increase side effects.
Tizanidine carries more major-labeled pairs than Drospirenone
SPL source-record counts only. This page's band is minor · classes on file: Drospirenone (Combined Oral Contraceptive); Tizanidine (Central Alpha-2 Agonist (Muscle Relaxant)).
Tizanidine has 2 major-labeled pairs vs Drospirenone's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 29 minor · 30 total
- Other minor peers for Drospirenone
- Atorvastatin
- Omeprazole
- Lamotrigine
- Topiramate
2 major · 1 moderate · 14 minor · 17 total
- Other minor peers for Tizanidine
- Acyclovir
- Verapamil
- Amiodarone
- Propafenone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.