Dolutegravir and Dofetilide Interaction
Drug interaction information between Dolutegravir and Dofetilide.
Dolutegravir and Dofetilide have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Dolutegravir and Dofetilide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Dolutegravir blocks the proteins in the kidneys that normally help remove dofetilide from the body. This causes the levels of dofetilide in your blood to rise.
FDA Label Information
Dolutegravir may increase plasma concentrations of drugs eliminated via OCT2 or MATE1 (dofetilide, dalfampridine, and metformin) [see Contraindications ( 4 ), Drug Interactions ( 7.3 )] . Other Agents Antiarrhythmic: Dofetilide ↑Dofetilide Coadministration is contraindicated with TRIUMEQ and TRIUMEQ PD [see Contraindications ( 4 )] .
Dolutegravir Also Interacts With
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
- Linagliptin moderate
- Metformin/Empagliflozin moderate
Dofetilide Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir major
- Dolutegravir/Lamivudine major
- Itraconazole major
- Clarithromycin moderate
- Digoxin moderate
Frequently Asked Questions
What SPL severity band is on file for Dolutegravir + Dofetilide?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dolutegravir has 28 labeled pairs on file vs Dofetilide's 8. In the major band specifically: Dolutegravir has 1; Dofetilide has 4 (also Bictegravir, Dolutegravir/Lamivudine, Itraconazole).
What mechanism field is on file for Dolutegravir and Dofetilide?
Dolutegravir blocks the proteins in the kidneys that normally help remove dofetilide from the body. This causes the levels of dofetilide in your blood to rise.
Dofetilide carries more major-labeled pairs than Dolutegravir
SPL source-record counts only. This page's band is major · classes on file: Dolutegravir (Integrase Strand Transfer Inhibitor); Dofetilide (Class III Antiarrhythmic).
Dofetilide has 4 major-labeled pairs vs Dolutegravir's 1.
1 major · 6 moderate · 21 minor · 28 total
Dolutegravir has no other major-band peer in this dataset besides Dofetilide.
4 major · 3 moderate · 1 minor · 8 total
- Other major peers for Dofetilide
- Bictegravir
- Dolutegravir/Lamivudine
- Itraconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.