Dolutegravir and Prednisone Interaction
Drug interaction information between Dolutegravir and Prednisone.
Dolutegravir and Prednisone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dolutegravir and Prednisone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Prednisone does not change how the body handles dolutegravir.
FDA Label Information
Darunavir/ritonavir, lopinavir/ritonavir, rilpivirine, tenofovir, boceprevir, prednisone, rifabutin, and omeprazole had no clinically significant effect on the pharmacokinetics of dolutegravir.
Dolutegravir Also Interacts With
- Dofetilide major
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
- Linagliptin moderate
Prednisone Also Interacts With
- Theophylline major
- Abiraterone minor
- Darunavir minor
- Fluconazole minor
- Montelukast minor
Frequently Asked Questions
What SPL severity band is on file for Dolutegravir + Prednisone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dolutegravir has 28 labeled pairs on file vs Prednisone's 9. In the minor band specifically: Dolutegravir has 21 (also Omeprazole, Estradiol, Carbamazepine, Rifampin); Prednisone has 8 (also Abiraterone, Darunavir, Fluconazole, Montelukast).
What mechanism field is on file for Dolutegravir and Prednisone?
Prednisone does not change how the body handles dolutegravir.
Dolutegravir's labeled portfolio outnumbers Prednisone
SPL source-record counts only. This page's band is minor · classes on file: Dolutegravir (Integrase Strand Transfer Inhibitor); Prednisone (Corticosteroid).
1 major · 6 moderate · 21 minor · 28 total
- Other minor peers for Dolutegravir
- Omeprazole
- Estradiol
- Carbamazepine
- Rifampin
1 major · 0 moderate · 8 minor · 9 total
- Other minor peers for Prednisone
- Abiraterone
- Darunavir
- Fluconazole
- Montelukast
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.