Desvenlafaxine and Lithium Interaction
Drug interaction information between Desvenlafaxine and Lithium.
Desvenlafaxine and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Desvenlafaxine and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications increase the amount of a chemical called serotonin in your brain. Taking them together can cause serotonin levels to become dangerously high.
FDA Label Information
Examples other SNRIs, SSRIs, triptans, tricyclic antidepressants, opioids, lithium, buspirone, amphetamines, tryptophan, and St.
Desvenlafaxine Also Interacts With
- Aspirin moderate
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Desvenlafaxine + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Desvenlafaxine's 19. In the minor band specifically: Desvenlafaxine has 13 (also Metoprolol, Buspirone, Aripiprazole, Atomoxetine); Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Candesartan).
What mechanism field is on file for Desvenlafaxine and Lithium?
Both of these medications increase the amount of a chemical called serotonin in your brain. Taking them together can cause serotonin levels to become dangerously high.
Lithium carries more major-labeled pairs than Desvenlafaxine
SPL source-record counts only. This page's band is minor · classes on file: Desvenlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Desvenlafaxine's 0. This page itself is in the minor band, not the major band.
0 major · 6 moderate · 13 minor · 19 total
- Other minor peers for Desvenlafaxine
- Metoprolol
- Buspirone
- Aripiprazole
- Atomoxetine
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.