darunavir vs desipramine
Side-by-side comparison of darunavir and desipramine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Tricyclic Antidepressants (TCAs): amitriptyline, desipramine, imipramine, nortriptyline ↑ amitriptyline ↑ desipramine ↑ imipramine ↑ nortriptyline Use a lower dose of the tricyclic antidepressants and trazodone due to potential increased adverse events such as nausea, dizziness, hypotension and syncope.
Recommendation: Your doctor should use a lower dose of desipramine and watch for side effects like dizziness or fainting.
Prezista
Norpramin
Darunavir is a medicine used to treat HIV. It belongs to a class of drugs called protease inhibitors and must be taken with ritonavir.
Desipramine is a medicine used to treat depression. It belongs to a class of drugs called tricyclic antidepressants.
Darunavir is used to treat HIV-1 infection in adults and children 3 years and older. It must be taken with ritonavir and other HIV medicines. Darunavir helps to lower the amount of HIV in your body.
Desipramine is used to treat depression. Depression can cause feelings of sadness, loss of interest, and trouble functioning in daily life. This medicine can help improve your mood and overall well-being.
Darunavir is a protease inhibitor. It works by blocking an enzyme called protease that HIV needs to make copies of itself. This helps to slow down the spread of HIV in your body.
Desipramine works by affecting certain chemicals in the brain. It helps to increase the levels of norepinephrine. This can improve mood and reduce symptoms of depression.
- • Diarrhea
- • Nausea
- • Rash
- • Headache
- • Abdominal pain
- • Drowsiness
- • Dizziness
- • Dry mouth
- • Constipation
- • Blurred vision
- Baby exposed to drug during pregnancy 1,150
- Interaction between medicines 981
- Pain 889
- Emotional upset 812
- Worry 811
- Tiredness 119
- Death by suicide 116
- Feeling sick to your stomach 77
- Head pain 70
- Gaining weight 68
Darunavir can cause liver problems. Your doctor should check your liver before you start taking darunavir and during treatment. Tell your doctor right away if you have any signs of liver problems, such as yellowing of the skin or eyes.
Antidepressants may increase the risk of suicidal thoughts or actions in children, teens, and young adults. Watch for worsening depression, unusual behavior, or thoughts of suicide. Desipramine is not approved for use in children.
Tell your doctor if you are pregnant or plan to become pregnant. The recommended dose during pregnancy is 600 mg twice daily with ritonavir 100mg and food. Women with HIV should not breastfeed because HIV can be passed to the baby through breast milk.
Tell your doctor if you are pregnant or plan to become pregnant. Desipramine may affect your baby. Talk to your doctor about the risks and benefits of taking this medicine while pregnant or breastfeeding.
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How to Read This darunavir vs desipramine Comparison
darunavir is classified in the HIV Protease Inhibitor drug class, while desipramine sits within the Tricyclic Antidepressant (TCA) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, darunavir has 4,643 submissions while desipramine has 450. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to darunavir slows down the process your body uses to get rid of desipramine, leading to higher levels of the drug in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between darunavir and desipramine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.