Daptomycin and Simvastatin Interaction
Drug interaction information between Daptomycin and Simvastatin.
Daptomycin and Simvastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Daptomycin and Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can cause muscle damage on their own, so taking them together increases the risk of severe muscle breakdown.
FDA Label Information
Daptomycin Clinical Impact: Cases of rhabdomyolysis have been reported with simvastatin administered with daptomycin. Both ezetimibe and simvastatin and daptomycin can cause myopathy and rhabdomyolysis when given alone and the risk of myopathy and rhabdomyolysis may be increased by coadministration. Intervention: If treatment with daptomycin is required, consider temporarily suspending ezetimibe and simvastatin during the course of daptomycin treatment.
Daptomycin Also Interacts With
- Ezetimibe moderate
- Ezetimibe/Simvastatin moderate
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Daptomycin + Simvastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Daptomycin's 3. In the moderate band specifically: Daptomycin has 3 (also Ezetimibe, Ezetimibe/Simvastatin); Simvastatin has 9 (also Ezetimibe, Colchicine, Niacin, Bempedoic Acid).
What mechanism field is on file for Daptomycin and Simvastatin?
Both drugs can cause muscle damage on their own, so taking them together increases the risk of severe muscle breakdown.
Simvastatin carries more major-labeled pairs than Daptomycin
SPL source-record counts only. This page's band is moderate · classes on file: Daptomycin (Lipopeptide Antibiotic); Simvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Simvastatin has 11 major-labeled pairs vs Daptomycin's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 0 minor · 3 total
- Other moderate peers for Daptomycin
- Ezetimibe
- Ezetimibe/Simvastatin
11 major · 9 moderate · 21 minor · 41 total
- Other moderate peers for Simvastatin
- Ezetimibe
- Colchicine
- Niacin
- Bempedoic Acid
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.