daptomycin vs simvastatin
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Side-by-side comparison of daptomycin and simvastatin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Daptomycin Clinical Impact: Cases of rhabdomyolysis have been reported with simvastatin administered with daptomycin. Both ezetimibe and simvastatin and daptomycin can cause myopathy and rhabdomyolysis when given alone and the risk of myopathy and rhabdomyolysis may be increased by coadministration. Intervention: If treatment with daptomycin is required, consider temporarily suspending ezetimibe and simvastatin during the course of daptomycin treatment.
Cubicin
Zocor
Daptomycin is an antibiotic medicine. It fights certain bacterial infections in your body.
No summary available.
Daptomycin treats complicated skin infections in adults and children ages 1-17. It also treats Staphylococcus aureus bloodstream infections (bacteremia) in adults and children ages 1-17. Daptomycin is not used to treat pneumonia or left-sided heart infections.
Information not available.
Daptomycin works by attaching to the cell membrane of bacteria. This causes the bacterial cell membrane to become unstable. The instability stops the bacteria from growing, eventually killing it.
Information not available.
- • Diarrhea
- • Headache
- • Dizziness
- • Rash
- • Abnormal liver tests
- • Headache
- • Upper respiratory tract infection
- • Muscle pain
- • Diarrhea
- Acute Kidney Injury 527
- Pyrexia 459
- Eosinophilic Pneumonia 418
- Rhabdomyolysis 336
- Eosinophilia 328
- Fatigue 13,574
- Nausea 12,945
- Dyspnoea 12,431
- Diarrhoea 11,813
- Dizziness 10,971
Daptomycin can cause serious side effects. It can cause allergic reactions, muscle problems (myopathy and rhabdomyolysis), and a type of pneumonia (eosinophilic pneumonia). It can also cause severe skin reactions, kidney problems, nerve damage, and diarrhea from C. difficile. Tell your doctor right away if you have any of these side effects.
No specific warnings noted.
Tell your doctor if you are pregnant or breastfeeding. There is limited information about daptomycin use during pregnancy. Daptomycin does pass into breast milk in small amounts, but the effects on the baby are unknown.
No pregnancy information available.
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How to Read This daptomycin vs simvastatin Comparison
daptomycin is classified in the Lipopeptide Antibiotic drug class, while simvastatin sits within the HMG-CoA Reductase Inhibitor (Statin) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, daptomycin has 2,068 submissions while simvastatin has 61,734. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to both drugs can cause muscle damage on their own, so taking them together increases the risk of severe muscle breakdown.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for daptomycin or simvastatin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.