Dapsone Topical and Rifampin Interaction
Drug interaction information between Dapsone Topical and Rifampin.
Dapsone Topical and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dapsone Topical and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin can lower the levels of dapsone in your body by making your liver process the drug faster than usual.
FDA Label Information
7.3 Drug Interactions with Oral Dapsone Certain concomitant medications (such as rifampin, anticonvulsants, St.
Dapsone Topical Also Interacts With
- Acetaminophen moderate
- Nitrofurantoin moderate
- Chloroquine moderate
- Nitroglycerin moderate
- Phenytoin moderate
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Dapsone Topical + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Dapsone Topical's 10. In the minor band specifically: Dapsone Topical has 4 (also Folic Acid, Trimethoprim, Benzoyl Peroxide); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Dapsone Topical and Rifampin?
Rifampin can lower the levels of dapsone in your body by making your liver process the drug faster than usual.
Rifampin carries more major-labeled pairs than Dapsone Topical
SPL source-record counts only. This page's band is minor · classes on file: Dapsone Topical (Topical Anti-Inflammatory); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Dapsone Topical's 0. This page itself is in the minor band, not the major band.
0 major · 6 moderate · 4 minor · 10 total
- Other minor peers for Dapsone Topical
- Folic Acid
- Trimethoprim
- Benzoyl Peroxide
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.