Dapsone Topical and Folic Acid Interaction
Drug interaction information between Dapsone Topical and Folic Acid.
Dapsone Topical and Folic Acid have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dapsone Topical and Folic Acid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these drugs together can increase the chance of having blood problems because they both affect how your body handles folic acid.
FDA Label Information
With oral dapsone treatment, folic acid antagonists such as pyrimethamine have been noted to possibly increase the likelihood of hematologic reactions.
Dapsone Topical Also Interacts With
- Acetaminophen moderate
- Nitrofurantoin moderate
- Chloroquine moderate
- Nitroglycerin moderate
- Phenytoin moderate
Folic Acid Also Interacts With
- Infliximab minor
- Methotrexate minor
- Phenytoin minor
- Prenatal Multivitamin minor
Frequently Asked Questions
What SPL severity band is on file for Dapsone Topical + Folic Acid?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dapsone Topical has 10 labeled pairs on file vs Folic Acid's 5. In the minor band specifically: Dapsone Topical has 4 (also Trimethoprim, Rifampin, Benzoyl Peroxide); Folic Acid has 5 (also Infliximab, Methotrexate, Phenytoin, Prenatal Multivitamin).
What mechanism field is on file for Dapsone Topical and Folic Acid?
Using these drugs together can increase the chance of having blood problems because they both affect how your body handles folic acid.
Dapsone Topical's labeled portfolio outnumbers Folic Acid
SPL source-record counts only. This page's band is minor · classes on file: Dapsone Topical (Topical Anti-Inflammatory); Folic Acid (B Vitamin (Folate) Supplement).
0 major · 6 moderate · 4 minor · 10 total
- Other minor peers for Dapsone Topical
- Trimethoprim
- Rifampin
- Benzoyl Peroxide
0 major · 0 moderate · 5 minor · 5 total
- Other minor peers for Folic Acid
- Infliximab
- Methotrexate
- Phenytoin
- Prenatal Multivitamin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.