Dapsone Topical and Benzoyl Peroxide Interaction
Drug interaction information between Dapsone Topical and Benzoyl Peroxide.
Dapsone Topical and Benzoyl Peroxide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dapsone Topical and Benzoyl Peroxide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two skin treatments can react with each other on your skin to cause a temporary yellow or orange stain.
FDA Label Information
Topical benzoyl peroxide used at the same time as ACZONE Gel, 7.5% may result in temporary local yellow or orange skin discoloration ( 7.2 ). 7.2 Topical Benzoyl Peroxide Topical application of dapsone gel followed by benzoyl peroxide in patients with acne vulgaris may result in a temporary local yellow or orange discoloration of the skin and facial hair.
Dapsone Topical Also Interacts With
- Acetaminophen moderate
- Nitrofurantoin moderate
- Chloroquine moderate
- Nitroglycerin moderate
- Phenytoin moderate
Frequently Asked Questions
What SPL severity band is on file for Dapsone Topical + Benzoyl Peroxide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dapsone Topical has 10 labeled pairs on file vs Benzoyl Peroxide's 2. In the minor band specifically: Dapsone Topical has 4 (also Folic Acid, Trimethoprim, Rifampin); Benzoyl Peroxide has 2 (also Adapalene).
What mechanism field is on file for Dapsone Topical and Benzoyl Peroxide?
These two skin treatments can react with each other on your skin to cause a temporary yellow or orange stain.
Dapsone Topical's labeled portfolio outnumbers Benzoyl Peroxide
SPL source-record counts only. This page's band is minor · classes on file: Dapsone Topical (Topical Anti-Inflammatory); Benzoyl Peroxide (Antimicrobial (Topical)).
0 major · 6 moderate · 4 minor · 10 total
- Other minor peers for Dapsone Topical
- Folic Acid
- Trimethoprim
- Rifampin
0 major · 0 moderate · 2 minor · 2 total
- Other minor peers for Benzoyl Peroxide
- Adapalene
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.