Dapsone Topical and Chloroquine Interaction
Drug interaction information between Dapsone Topical and Chloroquine.
Dapsone Topical and Chloroquine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Dapsone Topical and Chloroquine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs can interfere with the way your red blood cells deliver oxygen to your body. Combining them increases the risk of a serious blood disorder.
FDA Label Information
7.4 Concomitant Use with Drugs that Induce Methemoglobinemia Concomitant use of ACZONE Gel, 7.5% with drugs that induce methemoglobinemia such as sulfonamides, acetaminophen, acetanilide, aniline dyes, benzocaine, chloroquine, dapsone, naphthalene, nitrates and nitrites, nitrofurantoin, nitroglycerin, nitroprusside, pamaquine, para‐aminosalicylic acid, phenacetin, phenobarbital, phenytoin, primaquine, and quinine may increase the risk for developing methemoglobinemia [see Warnings and Precautions ( 5.1 )] .
Dapsone Topical Also Interacts With
- Acetaminophen moderate
- Nitrofurantoin moderate
- Nitroglycerin moderate
- Phenytoin moderate
- Phenobarbital moderate
Chloroquine Also Interacts With
- Hydroxychloroquine moderate
- Lidocaine Topical moderate
- Remdesivir moderate
- Methylprednisolone minor
Frequently Asked Questions
What SPL severity band is on file for Dapsone Topical + Chloroquine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dapsone Topical has 10 labeled pairs on file vs Chloroquine's 5. In the moderate band specifically: Dapsone Topical has 6 (also Acetaminophen, Nitrofurantoin, Nitroglycerin, Phenytoin); Chloroquine has 4 (also Hydroxychloroquine, Lidocaine Topical, Remdesivir).
What mechanism field is on file for Dapsone Topical and Chloroquine?
Both of these drugs can interfere with the way your red blood cells deliver oxygen to your body. Combining them increases the risk of a serious blood disorder.
Dapsone Topical's labeled portfolio outnumbers Chloroquine
SPL source-record counts only. This page's band is moderate · classes on file: Dapsone Topical (Topical Anti-Inflammatory); Chloroquine (Antimalarial).
0 major · 6 moderate · 4 minor · 10 total
- Other moderate peers for Dapsone Topical
- Acetaminophen
- Nitrofurantoin
- Nitroglycerin
- Phenytoin
0 major · 4 moderate · 1 minor · 5 total
- Other moderate peers for Chloroquine
- Hydroxychloroquine
- Lidocaine Topical
- Remdesivir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.