Dapsone Topical and Acetaminophen Interaction
Drug interaction information between Dapsone Topical and Acetaminophen.
Dapsone Topical and Acetaminophen have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Dapsone Topical and Acetaminophen. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can cause a rare blood condition where red blood cells cannot carry oxygen properly. Taking them together increases the risk of this problem occurring.
FDA Label Information
7.4 Concomitant Use with Drugs that Induce Methemoglobinemia Concomitant use of ACZONE Gel, 7.5% with drugs that induce methemoglobinemia such as sulfonamides, acetaminophen, acetanilide, aniline dyes, benzocaine, chloroquine, dapsone, naphthalene, nitrates and nitrites, nitrofurantoin, nitroglycerin, nitroprusside, pamaquine, para‐aminosalicylic acid, phenacetin, phenobarbital, phenytoin, primaquine, and quinine may increase the risk for developing methemoglobinemia [see Warnings and Precautions ( 5.1 )] .
Dapsone Topical Also Interacts With
- Nitrofurantoin moderate
- Chloroquine moderate
- Nitroglycerin moderate
- Phenytoin moderate
- Phenobarbital moderate
Acetaminophen Also Interacts With
- Lidocaine Topical moderate
- Acetaminophen/Oxycodone minor
- Carbamazepine minor
- Cidofovir minor
- Codeine minor
Frequently Asked Questions
What SPL severity band is on file for Dapsone Topical + Acetaminophen?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Acetaminophen has 23 labeled pairs on file vs Dapsone Topical's 10. In the moderate band specifically: Dapsone Topical has 6 (also Nitrofurantoin, Chloroquine, Nitroglycerin, Phenytoin); Acetaminophen has 2 (also Lidocaine Topical).
What mechanism field is on file for Dapsone Topical and Acetaminophen?
Both drugs can cause a rare blood condition where red blood cells cannot carry oxygen properly. Taking them together increases the risk of this problem occurring.
Acetaminophen's labeled portfolio outnumbers Dapsone Topical
SPL source-record counts only. This page's band is moderate · classes on file: Dapsone Topical (Topical Anti-Inflammatory); Acetaminophen (Analgesic / Antipyretic).
0 major · 6 moderate · 4 minor · 10 total
- Other moderate peers for Dapsone Topical
- Nitrofurantoin
- Chloroquine
- Nitroglycerin
- Phenytoin
0 major · 2 moderate · 21 minor · 23 total
- Other moderate peers for Acetaminophen
- Lidocaine Topical
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.