Allopurinol and Pegloticase Interaction
Drug interaction information between Allopurinol and Pegloticase.
Allopurinol and Pegloticase have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Allopurinol and Pegloticase. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Allopurinol can hide changes in your blood levels that warn doctors of a possible severe allergic reaction to pegloticase.
FDA Label Information
( 7.2 ) Pegloticase: Discontinue and refrain from initiating treatment with allopurinol tablets. Pegloticase Clinical Impact Concomitant use of allopurinol tablets and pegloticase may potentially blunt the rise of serum uric acid levels and increase the risk of pegloticase related anaphylaxis in patients whose uric acid level increase to above 6 mg/dL. Intervention Discontinue and do not institute allopurinol tablets therapy during treatment with pegloticase.
Allopurinol Also Interacts With
- Cyclosporine moderate
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Warfarin minor
- Theophylline minor
Frequently Asked Questions
What SPL severity band is on file for Allopurinol + Pegloticase?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Allopurinol has 10 labeled pairs on file vs Pegloticase's 2. In the major band specifically: Allopurinol has 1; Pegloticase has 1.
What mechanism field is on file for Allopurinol and Pegloticase?
Allopurinol can hide changes in your blood levels that warn doctors of a possible severe allergic reaction to pegloticase.
Allopurinol's labeled portfolio outnumbers Pegloticase
SPL source-record counts only. This page's band is major · classes on file: Allopurinol (Xanthine Oxidase Inhibitor); Pegloticase (Recombinant Uricase).
1 major · 3 moderate · 6 minor · 10 total
Allopurinol has no other major-band peer in this dataset besides Pegloticase.
1 major · 0 moderate · 1 minor · 2 total
Pegloticase has no other major-band peer in this dataset besides Allopurinol.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.