Adalimumab and Theophylline Interaction
Drug interaction information between Adalimumab and Theophylline.
Adalimumab and Theophylline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Adalimumab and Theophylline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medicine can affect the way your body processes theophylline, which might lead to levels that are too high or too low.
FDA Label Information
Upon initiation or discontinuation of IDACIO in patients being treated with CYP450 substrates with a narrow therapeutic index, monitoring of the effect (e.g., warfarin) or drug concentration (e.g., cyclosporine or theophylline) is recommended and the individual dose of the drug product may be adjusted as needed.
Adalimumab Also Interacts With
- Abatacept moderate
- Warfarin minor
- Methotrexate minor
- Cyclosporine minor
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Omeprazole major
- Amoxicillin major
- Famotidine major
Frequently Asked Questions
What SPL severity band is on file for Adalimumab + Theophylline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Theophylline has 86 labeled pairs on file vs Adalimumab's 5. In the minor band specifically: Adalimumab has 4 (also Warfarin, Methotrexate, Cyclosporine); Theophylline has 54 (also Propranolol, Methotrexate, Diazepam, Lithium).
What mechanism field is on file for Adalimumab and Theophylline?
This medicine can affect the way your body processes theophylline, which might lead to levels that are too high or too low.
Theophylline carries more major-labeled pairs than Adalimumab
SPL source-record counts only. This page's band is minor · classes on file: Adalimumab (TNF-Alpha Inhibitor (Biologic)); Theophylline (Methylxanthine Bronchodilator).
Theophylline has 27 major-labeled pairs vs Adalimumab's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 4 minor · 5 total
- Other minor peers for Adalimumab
- Warfarin
- Methotrexate
- Cyclosporine
27 major · 5 moderate · 54 minor · 86 total
- Other minor peers for Theophylline
- Propranolol
- Methotrexate
- Diazepam
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.