Adalimumab and Abatacept Interaction
Drug interaction information between Adalimumab and Abatacept.
Adalimumab and Abatacept have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Adalimumab and Abatacept. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs lower your body's ability to fight germs. Taking them together increases your risk of getting a very serious infection without helping your symptoms more.
FDA Label Information
7 DRUG INTERACTIONS • Abatacept: Increased risk of serious infection. 7.2 Biological Products In clinical studies in patients with RA, an increased risk of serious infections has been observed with the combination of TNF blockers with anakinra or abatacept, with no added benefit; therefore, use of IDACIO with abatacept or anakinra is not recommended in patients with RA [see Warnings and Precautions ( 5.7 , 5.11 )] . Concomitant administration of IDACIO with other biologic DMARDS (e.g., anakinra and abatacept) or other TNF blockers is not recommended based upon the possible increased risk...
Adalimumab Also Interacts With
- Warfarin minor
- Methotrexate minor
- Cyclosporine minor
- Theophylline minor
Abatacept Also Interacts With
- Certolizumab moderate
- Etanercept moderate
- Golimumab moderate
- Infliximab moderate
Frequently Asked Questions
What SPL severity band is on file for Adalimumab + Abatacept?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's moderate band?
Adalimumab and Abatacept tie at 5 labeled pairs each. moderate-band counts: Adalimumab 1; Abatacept 5 alongside Certolizumab, Etanercept, Golimumab, Infliximab.
What mechanism field is on file for Adalimumab and Abatacept?
Both drugs lower your body's ability to fight germs. Taking them together increases your risk of getting a very serious infection without helping your symptoms more.
Adalimumab and Abatacept · moderate-band peers
SPL source-record counts only. This page's band is moderate · classes on file: Adalimumab (TNF-Alpha Inhibitor (Biologic)); Abatacept (T-Cell Co-Stimulation Modulator).
0 major · 1 moderate · 4 minor · 5 total
Adalimumab has no other moderate-band peer in this dataset besides Abatacept.
0 major · 5 moderate · 0 minor · 5 total
- Other moderate peers for Abatacept
- Certolizumab
- Etanercept
- Golimumab
- Infliximab
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.