Adalimumab and Warfarin Interaction
Drug interaction information between Adalimumab and Warfarin.
Adalimumab and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Adalimumab and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Adalimumab can change how your body processes other drugs like warfarin, which could make the blood thinner more or less effective.
FDA Label Information
Upon initiation or discontinuation of IDACIO in patients being treated with CYP450 substrates with a narrow therapeutic index, monitoring of the effect (e.g., warfarin) or drug concentration (e.g., cyclosporine or theophylline) is recommended and the individual dose of the drug product may be adjusted as needed.
Adalimumab Also Interacts With
- Abatacept moderate
- Methotrexate minor
- Cyclosporine minor
- Theophylline minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Adalimumab + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Adalimumab's 5. In the minor band specifically: Adalimumab has 4 (also Methotrexate, Cyclosporine, Theophylline); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Adalimumab and Warfarin?
Adalimumab can change how your body processes other drugs like warfarin, which could make the blood thinner more or less effective.
Warfarin carries more major-labeled pairs than Adalimumab
SPL source-record counts only. This page's band is minor · classes on file: Adalimumab (TNF-Alpha Inhibitor (Biologic)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Adalimumab's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 4 minor · 5 total
- Other minor peers for Adalimumab
- Methotrexate
- Cyclosporine
- Theophylline
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.