What the FDA labels say about taking them together
Colesevelam and olmesartan
Colesevelam's FDA label of December 28, 2023 names olmesartan in its drug interactions section, and olmesartan's label names colesevelam too. The colesevelam label: “In vivo drug interactions studies showed a decrease in olmesartan medoxomil when coadministered with colesevelam hydrochloride.”
Check it at the source: the colesevelam FDA label on DailyMed (effective December 28, 2023, A-S Medication Solutions); the olmesartan FDA label on DailyMed (effective September 23, 2025, Cosette Pharmaceuticals, Inc.).
What does the colesevelam label say about olmesartan?
Colesevelam label, drug interactionsOlmesartan Medoxomil Clinical Impact: In vivo drug interactions studies showed a decrease in olmesartan medoxomil when coadministered with colesevelam hydrochloride. Intervention: Administer olmesartan medoxomil 4 hours prior to colesevelam hydrochloride.
Source: FDA drug label (COLESEVELAM HYDROCHLORIDE), NDA021176 (Cosette), as published by A-S Medication Solutions, effective December 28, 2023 (SPL set 0127afae-8d8d-43f2-97f9-4f99f6947e81), via openFDA; the full label on DailyMed
What does the olmesartan label say about colesevelam?
Olmesartan label, drug interactionsConcurrent administration of bile acid sequestering agent colesevelam hydrochloride reduces the systemic exposure and peak plasma concentration of olmesartan.
Source: FDA drug label (Benicar), Cosette Pharmaceuticals, Inc., effective September 23, 2025 (SPL set dc3f1fd4-5578-4c5d-be7b-12e3f8f3e7df), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Colesevelam | Olmesartan | |
|---|---|---|
| Labeled for | High cholesterol, Type 2 diabetes | High blood pressure |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.262 per tablet 625 mg tablet | $0.0805 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once