Olmesartan and Aliskiren Interaction
Drug interaction information between Olmesartan and Aliskiren.
Olmesartan and Aliskiren have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Olmesartan and Aliskiren. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs block the same system that controls blood pressure, which can put too much strain on your kidneys. This increases the risk of dangerously low blood pressure and high potassium levels.
FDA Label Information
7.4 Dual Blockade of the Renin Angiotensin System Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not co-administer aliskiren with olmesartan medoxomil and hydrochlorothiazide in patients with diabetes [see Contraindications (4) ]. Avoid use of aliskiren with olmesartan medoxomil and hydrochlorothiazide in patients with renal impairment (GFR <60 ml/min).
Olmesartan Also Interacts With
- Hydrochlorothiazide moderate
- Lithium moderate
- Colesevelam moderate
- Cholestyramine moderate
- Colestipol moderate
Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Amlodipine/Valsartan major
- Azilsartan major
- Benazepril major
- Candesartan major
Frequently Asked Questions
What SPL severity band is on file for Olmesartan + Aliskiren?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aliskiren has 28 labeled pairs on file vs Olmesartan's 7. In the major band specifically: Olmesartan has 1; Aliskiren has 22 (also Amlodipine/Benazepril, Amlodipine/Valsartan, Azilsartan, Benazepril).
What mechanism field is on file for Olmesartan and Aliskiren?
Both drugs block the same system that controls blood pressure, which can put too much strain on your kidneys. This increases the risk of dangerously low blood pressure and high potassium levels.
Aliskiren carries more major-labeled pairs than Olmesartan
SPL source-record counts only. This page's band is major · classes on file: Olmesartan (Angiotensin II Receptor Blocker (ARB)); Aliskiren (Direct Renin Inhibitor).
Aliskiren has 22 major-labeled pairs vs Olmesartan's 1.
1 major · 6 moderate · 0 minor · 7 total
Olmesartan has no other major-band peer in this dataset besides Aliskiren.
22 major · 3 moderate · 3 minor · 28 total
- Other major peers for Aliskiren
- Amlodipine/Benazepril
- Amlodipine/Valsartan
- Azilsartan
- Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.