Olmesartan and Cholestyramine Interaction
Drug interaction information between Olmesartan and Cholestyramine.
Olmesartan and Cholestyramine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Olmesartan and Cholestyramine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cholestyramine can trap other medicines in your gut, which prevents your body from absorbing them properly. This can make your blood pressure medicine less effective.
FDA Label Information
7 DRUG INTERACTIONS Lithium: Risk of lithium toxicity ( 7.2 ) Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Reduced diuretic, natriuretic and antihypotensive effects; increased risk of renal toxicity ( 7.3 ) Dual inhibition of the renin-angiotensin system: Increased risk of renal impairment, hypotension, and hyperkalemia ( 7.4 ) Colesevelam hydrochloride: Consider administering olmesartan at least 4 hours before colesevelam hydrochloride dose ( 7.5 ) Antidiabetic drugs: Dosage adjustment may be required ( 7.6 ) Cholestyramine and colestipol: Reduced absorption of thiazides ( 7.6 ) 7.1...
Olmesartan Also Interacts With
- Aliskiren major
- Hydrochlorothiazide moderate
- Lithium moderate
- Colesevelam moderate
- Colestipol moderate
Cholestyramine Also Interacts With
- Naproxen moderate
- Raloxifene moderate
- Propranolol minor
- Warfarin minor
- Tetracycline minor
Frequently Asked Questions
What SPL severity band is on file for Olmesartan + Cholestyramine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cholestyramine has 34 labeled pairs on file vs Olmesartan's 7. In the moderate band specifically: Olmesartan has 6 (also Hydrochlorothiazide, Lithium, Colesevelam, Colestipol); Cholestyramine has 3 (also Naproxen, Raloxifene).
What mechanism field is on file for Olmesartan and Cholestyramine?
Cholestyramine can trap other medicines in your gut, which prevents your body from absorbing them properly. This can make your blood pressure medicine less effective.
Olmesartan carries more major-labeled pairs than Cholestyramine
SPL source-record counts only. This page's band is moderate · classes on file: Olmesartan (Angiotensin II Receptor Blocker (ARB)); Cholestyramine (Bile Acid Sequestrant).
Olmesartan has 1 major-labeled pair vs Cholestyramine's 0. This page itself is in the moderate band, not the major band.
1 major · 6 moderate · 0 minor · 7 total
- Other moderate peers for Olmesartan
- Hydrochlorothiazide
- Lithium
- Colesevelam
- Colestipol
0 major · 3 moderate · 31 minor · 34 total
- Other moderate peers for Cholestyramine
- Naproxen
- Raloxifene
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.