Colesevelam and Glyburide Interaction
Drug interaction information between Colesevelam and Glyburide.
Colesevelam and Glyburide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Colesevelam and Glyburide. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Colesevelam can lower the amount of diabetes medicine your body absorbs into the bloodstream. This can make the medicine less effective at controlling your blood sugar.
What To Do
Monitor your blood sugar levels carefully while taking both medications. Your doctor may need to adjust your dose or the timing of your medicine.
FDA Label Information
7 DRUG INTERACTIONS Concomitant use with colesevelam hydrochloride may decrease the exposure of the following drugs: Drugs with a narrow therapeutic index (e.g., cyclosporine), phenytoin, thyroid hormone replacement therapy, warfarin, oral contraceptives containing ethinyl estradiol and norethindrone, olmesartan medoxomil, and sulfonylureas (glimepiride, glipizide, glyburide). Examples: Glimepiride, glipizide, and glyburide Oral Vitamin Supplements Clinical Impact: Colesevelam hydrochloride may decrease the absorption of fat-soluble vitamins A, D, E, and K [see Warnings and Precautions...
Colesevelam Also Interacts With
- Olmesartan moderate
- Metformin minor
- Warfarin minor
- Norethindrone minor
- Cyclosporine minor
Glyburide Also Interacts With
- Fluvastatin moderate
- Eprosartan minor
- Etodolac minor
- Fluconazole minor
- Miglitol minor
Frequently Asked Questions
Can I take Colesevelam and Glyburide together?
This is a minor interaction. Monitor your blood sugar levels carefully while taking both medications. Your doctor may need to adjust your dose or the timing of your medicine.
How serious is the interaction between Colesevelam and Glyburide?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Colesevelam and Glyburide interact?
Colesevelam can lower the amount of diabetes medicine your body absorbs into the bloodstream. This can make the medicine less effective at controlling your blood sugar.
Understanding the Colesevelam and Glyburide Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Colesevelam belongs to the Bile Acid Sequestrant (Diabetes) class and Glyburide belongs to the Sulfonylurea class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Colesevelam can lower the amount of diabetes medicine your body absorbs into the bloodstream. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Colesevelam has 15 total documented interactions on file in this dataset, and Glyburide has 9. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Monitor your blood sugar levels carefully while taking both medications. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Colesevelam or Glyburide based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.