What the FDA labels say about taking them together
Colesevelam and glyburide
Colesevelam's FDA label of December 28, 2023 names glyburide in its drug interactions section, and glyburide's label names colesevelam too. The colesevelam label: “In vivo drug interactions studies showed a decrease in sulfonylureas when coadministered with colesevelam hydrochloride.”
Check it at the source: the colesevelam FDA label on DailyMed (effective December 28, 2023, A-S Medication Solutions); the glyburide FDA label on DailyMed (effective July 1, 2021, TEVA Pharmaceuticals USA Inc).
What does the colesevelam label say about glyburide?
Colesevelam label, drug interactionsSulfonylureas Clinical Impact: In vivo drug interactions studies showed a decrease in sulfonylureas when coadministered with colesevelam hydrochloride. Intervention: Administer sulfonylureas 4 hours prior to colesevelam hydrochloride. Examples: Glimepiride, glipizide, and glyburide
Source: FDA drug label (COLESEVELAM HYDROCHLORIDE), NDA021176 (Cosette), as published by A-S Medication Solutions, effective December 28, 2023 (SPL set 0127afae-8d8d-43f2-97f9-4f99f6947e81), via openFDA; the full label on DailyMed
What does the glyburide label say about colesevelam?
Glyburide label, drug interactionsColesevelam Concomitant administration of colesevelam and glyburide resulted in reductions in glyburide AUC and C max of 32% and 47%, respectively.
Source: FDA drug label (Glyburide), NDA017532 (Sanofi Aventis Us), as published by TEVA Pharmaceuticals USA Inc, effective July 1, 2021 (SPL set 50d16f1d-c814-4411-8749-62561321ecce), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Colesevelam | Glyburide | |
|---|---|---|
| Labeled for | High cholesterol, Type 2 diabetes | Type 2 diabetes |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.262 per tablet 625 mg tablet | $0.0643 per tablet 5 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once