Colesevelam and Glyburide Interaction
Drug interaction information between Colesevelam and Glyburide.
Colesevelam and Glyburide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Colesevelam and Glyburide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Colesevelam can lower the amount of diabetes medicine your body absorbs into the bloodstream. This can make the medicine less effective at controlling your blood sugar.
FDA Label Information
7 DRUG INTERACTIONS Concomitant use with colesevelam hydrochloride may decrease the exposure of the following drugs: Drugs with a narrow therapeutic index (e.g., cyclosporine), phenytoin, thyroid hormone replacement therapy, warfarin, oral contraceptives containing ethinyl estradiol and norethindrone, olmesartan medoxomil, and sulfonylureas (glimepiride, glipizide, glyburide). Examples: Glimepiride, glipizide, and glyburide Oral Vitamin Supplements Clinical Impact: Colesevelam hydrochloride may decrease the absorption of fat-soluble vitamins A, D, E, and K [see Warnings and Precautions...
Colesevelam Also Interacts With
- Olmesartan moderate
- Metformin minor
- Warfarin minor
- Norethindrone minor
- Cyclosporine minor
Glyburide Also Interacts With
- Fluvastatin moderate
- Eprosartan minor
- Etodolac minor
- Fluconazole minor
- Miglitol minor
Frequently Asked Questions
What SPL severity band is on file for Colesevelam + Glyburide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Colesevelam has 15 labeled pairs on file vs Glyburide's 9. In the minor band specifically: Colesevelam has 14 (also Metformin, Warfarin, Norethindrone, Cyclosporine); Glyburide has 8 (also Eprosartan, Etodolac, Fluconazole, Miglitol).
What mechanism field is on file for Colesevelam and Glyburide?
Colesevelam can lower the amount of diabetes medicine your body absorbs into the bloodstream. This can make the medicine less effective at controlling your blood sugar.
Colesevelam's labeled portfolio outnumbers Glyburide
SPL source-record counts only. This page's band is minor · classes on file: Colesevelam (Bile Acid Sequestrant (Diabetes)); Glyburide (Sulfonylurea).
0 major · 1 moderate · 14 minor · 15 total
- Other minor peers for Colesevelam
- Metformin
- Warfarin
- Norethindrone
- Cyclosporine
0 major · 1 moderate · 8 minor · 9 total
- Other minor peers for Glyburide
- Eprosartan
- Etodolac
- Fluconazole
- Miglitol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.