colesevelam vs glyburide
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Side-by-side comparison of colesevelam and glyburide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7 DRUG INTERACTIONS Concomitant use with colesevelam hydrochloride may decrease the exposure of the following drugs: Drugs with a narrow therapeutic index (e.g., cyclosporine), phenytoin, thyroid hormone replacement therapy, warfarin, oral contraceptives containing ethinyl estradiol and norethindrone, olmesartan medoxomil, and sulfonylureas (glimepiride, glipizide, glyburide). Examples: Glimepiride, glipizide, and glyburide Oral Vitamin Supplements Clinical Impact: Colesevelam hydrochloride may decrease the absorption of fat-soluble vitamins A, D, E, and K [see Warnings and Precautions...
Welchol
DiaBeta, Glynase
Colesevelam is a medicine that helps lower bad cholesterol (LDL-C) and control blood sugar in adults. It can also lower LDL-C in children ages 10-17 with certain cholesterol problems.
Glyburide is a medicine that helps lower blood sugar in adults with type 2 diabetes. It works along with diet and exercise.
This medicine can help lower high LDL cholesterol in adults and children (10-17 years old) who have primary hyperlipidemia or heterozygous familial hypercholesterolemia. These conditions mean you have high levels of bad cholesterol in your blood. Colesevelam can also help improve blood sugar control in adults with type 2 diabetes.
Glyburide is used to help control blood sugar levels in adults who have type 2 diabetes. It is prescribed in addition to diet and exercise. This medicine helps your body use insulin better, which lowers your blood sugar.
Colesevelam is a bile acid sequestrant. It works by binding to bile acids in your gut. This helps your body get rid of cholesterol and can also lower blood sugar levels.
Glyburide belongs to a class of drugs called sulfonylureas. It works by helping your pancreas release more insulin. Insulin then helps move sugar from your blood into your cells for energy.
- • Constipation
- • Upset stomach
- • Nausea
- • Accidental injury
- • Weakness
- • Nausea
- • Heartburn
- • Fullness in your upper abdomen
- Diarrhoea 121
- Dyspnoea 72
- Cough 64
- Muscle Spasms 61
- Fatigue 59
- Blood Glucose Increased 3,038
- Nausea 2,019
- Weight Decreased 1,537
- Diarrhoea 1,282
- Dizziness 1,201
Colesevelam can raise your triglyceride levels, which could cause pancreatitis. Tell your doctor right away if you have severe stomach pain. This medicine may also cause bowel obstruction, especially if you have stomach problems or have had major surgery on your stomach or intestines. Colesevelam can also lower the amount of fat-soluble vitamins your body absorbs.
Oral diabetes medicines like glyburide may increase your risk of heart problems, compared to treatment with diet alone or diet plus insulin. Talk to your doctor about the risks and benefits of taking glyburide.
This medicine is not absorbed into your body, so it is not expected to harm your baby during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. This medicine is also not expected to pass into breast milk.
Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if glyburide will harm your unborn baby. Talk to your doctor if you are breastfeeding.
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How to Read This colesevelam vs glyburide Comparison
colesevelam is classified in the Bile Acid Sequestrant (Diabetes) drug class, while glyburide sits within the Sulfonylurea class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, colesevelam has 377 submissions while glyburide has 9,077. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to colesevelam can lower the amount of diabetes medicine your body absorbs into the bloodstream. this can make the medicine less effective at controlling your blood sugar.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for colesevelam or glyburide.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.