Temazepam and Estradiol Interaction
Drug interaction information between Temazepam and Estradiol.
Temazepam and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Temazepam and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Estradiol can cause your body to get rid of temazepam faster than usual, which might make it less effective.
FDA Label Information
Other Drugs Clinical effect Concomitant use of COCs may decrease systemic exposure of acetaminophen, morphine, salicylic acid, and temazepam.
Temazepam Also Interacts With
- Clarithromycin minor
- Duloxetine minor
- Ethinyl Estradiol/Etonogestrel minor
- Ethinyl Estradiol/Norgestimate minor
- Etonogestrel minor
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Temazepam + Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Temazepam's 7. In the minor band specifically: Temazepam has 7 (also Clarithromycin, Duloxetine, Ethinyl Estradiol, Ethinyl Estradiol); Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine).
What mechanism field is on file for Temazepam and Estradiol?
Estradiol can cause your body to get rid of temazepam faster than usual, which might make it less effective.
Estradiol carries more major-labeled pairs than Temazepam
SPL source-record counts only. This page's band is minor · classes on file: Temazepam (Benzodiazepine (Hypnotic)); Estradiol (Estrogen Hormone).
Estradiol has 1 major-labeled pair vs Temazepam's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Temazepam
- Clarithromycin
- Duloxetine
- Ethinyl Estradiol
- Ethinyl Estradiol
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.