Temazepam and Ethinyl Estradiol Interaction
Drug interaction information between Temazepam and Ethinyl Estradiol.
Temazepam and Ethinyl Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Temazepam and Ethinyl Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Birth control hormones can cause your body to clear out this sleep medicine faster than it should. This can make the sleep medicine feel weaker or not work at all.
FDA Label Information
CHCs have been shown to decrease plasma concentrations of acetaminophen, clofibric acid, morphine, salicylic acid and temazepam.
Temazepam Also Interacts With
- Clarithromycin minor
- Duloxetine minor
- Estradiol minor
- Ethinyl Estradiol/Norgestimate minor
- Etonogestrel minor
Ethinyl Estradiol Also Interacts With
- Glecaprevir/Pibrentasvir moderate
- Atorvastatin minor
- Amoxicillin minor
- Estradiol minor
- Lamotrigine minor
Frequently Asked Questions
What SPL severity band is on file for Temazepam + Ethinyl Estradiol/Etonogestrel?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ethinyl Estradiol has 28 labeled pairs on file vs Temazepam's 7. In the minor band specifically: Temazepam has 7 (also Clarithromycin, Duloxetine, Estradiol, Ethinyl Estradiol); Ethinyl Estradiol has 27 (also Atorvastatin, Amoxicillin, Estradiol, Lamotrigine).
What mechanism field is on file for Temazepam and Ethinyl Estradiol/Etonogestrel?
Birth control hormones can cause your body to clear out this sleep medicine faster than it should. This can make the sleep medicine feel weaker or not work at all.
Ethinyl Estradiol's labeled portfolio outnumbers Temazepam
SPL source-record counts only. This page's band is minor · classes on file: Temazepam (Benzodiazepine (Hypnotic)); Ethinyl Estradiol (Vaginal Contraceptive Ring).
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Temazepam
- Clarithromycin
- Duloxetine
- Estradiol
- Ethinyl Estradiol
0 major · 1 moderate · 27 minor · 28 total
- Other minor peers for Ethinyl Estradiol
- Atorvastatin
- Amoxicillin
- Estradiol
- Lamotrigine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.