Temazepam and Duloxetine Interaction
Drug interaction information between Temazepam and Duloxetine.
Temazepam and Duloxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Temazepam and Duloxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two medications do not change how the body processes duloxetine when they are taken together.
FDA Label Information
7.6 Temazepam Under steady-state conditions for duloxetine (20 mg qhs) and temazepam (30 mg qhs), the pharmacokinetics of duloxetine were not affected by co-administration.
Temazepam Also Interacts With
- Clarithromycin minor
- Estradiol minor
- Ethinyl Estradiol/Etonogestrel minor
- Ethinyl Estradiol/Norgestimate minor
- Etonogestrel minor
Duloxetine Also Interacts With
- Aspirin moderate
- Fluoxetine minor
- Famotidine minor
- Buspirone minor
- Paroxetine minor
Frequently Asked Questions
What SPL severity band is on file for Temazepam + Duloxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Duloxetine has 18 labeled pairs on file vs Temazepam's 7. In the minor band specifically: Temazepam has 7 (also Clarithromycin, Estradiol, Ethinyl Estradiol, Ethinyl Estradiol); Duloxetine has 17 (also Fluoxetine, Famotidine, Buspirone, Paroxetine).
What mechanism field is on file for Temazepam and Duloxetine?
These two medications do not change how the body processes duloxetine when they are taken together.
Duloxetine's labeled portfolio outnumbers Temazepam
SPL source-record counts only. This page's band is minor · classes on file: Temazepam (Benzodiazepine (Hypnotic)); Duloxetine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Temazepam
- Clarithromycin
- Estradiol
- Ethinyl Estradiol
- Ethinyl Estradiol
0 major · 1 moderate · 17 minor · 18 total
- Other minor peers for Duloxetine
- Fluoxetine
- Famotidine
- Buspirone
- Paroxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.