What the FDA labels say about taking them together
Ciprofloxacin and duloxetine
Ciprofloxacin's FDA label of March 2, 2026 names duloxetine in its drug interactions section, and duloxetine's label names ciprofloxacin too. The ciprofloxacin label: “Duloxetine; Avoid Use Five-fold increase in duloxetine exposure; If unavoidable, monitor for duloxetine toxicity”
Check it at the source: the ciprofloxacin FDA label on DailyMed (effective March 2, 2026, Bayer HealthCare Pharmaceuticals Inc.); the duloxetine FDA label on DailyMed (effective May 14, 2024, SUN PHARMACEUTICAL INDUSTRIES, INC.).
What does the ciprofloxacin label say about duloxetine?
Ciprofloxacin label, drug interactionsDuloxetine; Avoid Use Five-fold increase in duloxetine exposure; If unavoidable, monitor for duloxetine toxicity
Source: FDA drug label (Cipro), Bayer HealthCare Pharmaceuticals Inc., effective March 2, 2026 (SPL set 888dc7f9-ad9c-4c00-8d50-8ddfd9bd27c0), via openFDA; the full label on DailyMed
What does the duloxetine label say about ciprofloxacin?
Duloxetine label, drug interactionsExamples; Fluvoxamine, cimetidine, ciprofloxacin, enoxacin
Source: FDA drug label (DRIZALMA SPRINKLE), SUN PHARMACEUTICAL INDUSTRIES, INC., effective May 14, 2024 (SPL set b41423b8-dfec-4d79-ba3c-e43a87803d85), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ciprofloxacin | Duloxetine | |
|---|---|---|
| Labeled for | Diarrhea, Urinary tract infections, Bacterial infections | Depression, Anxiety, Nerve pain and fibromyalgia, Pain |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.123 per tablet 500 mg tablet | $0.102 per capsule 30 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once