Ciprofloxacin and Duloxetine Interaction
Drug interaction information between Ciprofloxacin and Duloxetine.
Ciprofloxacin and Duloxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ciprofloxacin and Duloxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ciprofloxacin blocks a liver enzyme that usually breaks down duloxetine. This can cause the amount of duloxetine in your blood to rise.
FDA Label Information
Other drugs that inhibit CYP1A2 metabolism include cimetidine and quinolone antimicrobials such as ciprofloxacin and enoxacin [see Warnings and Precautions (5.12) ].
Ciprofloxacin Also Interacts With
- Tizanidine major
- Cyclosporine minor
- Theophylline minor
- Carbamazepine minor
- Clozapine minor
Duloxetine Also Interacts With
- Aspirin moderate
- Fluoxetine minor
- Famotidine minor
- Buspirone minor
- Paroxetine minor
Frequently Asked Questions
What SPL severity band is on file for Ciprofloxacin + Duloxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Duloxetine has 18 labeled pairs on file vs Ciprofloxacin's 14. In the minor band specifically: Ciprofloxacin has 13 (also Cyclosporine, Theophylline, Carbamazepine, Clozapine); Duloxetine has 17 (also Fluoxetine, Famotidine, Buspirone, Paroxetine).
What mechanism field is on file for Ciprofloxacin and Duloxetine?
Ciprofloxacin blocks a liver enzyme that usually breaks down duloxetine. This can cause the amount of duloxetine in your blood to rise.
Ciprofloxacin carries more major-labeled pairs than Duloxetine
SPL source-record counts only. This page's band is minor · classes on file: Ciprofloxacin (Fluoroquinolone Antibiotic); Duloxetine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
Ciprofloxacin has 1 major-labeled pair vs Duloxetine's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 13 minor · 14 total
- Other minor peers for Ciprofloxacin
- Cyclosporine
- Theophylline
- Carbamazepine
- Clozapine
0 major · 1 moderate · 17 minor · 18 total
- Other minor peers for Duloxetine
- Fluoxetine
- Famotidine
- Buspirone
- Paroxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.