Tizanidine and Amiodarone Interaction
Drug interaction information between Tizanidine and Amiodarone.
Tizanidine and Amiodarone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tizanidine and Amiodarone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amiodarone blocks the enzyme responsible for breaking down tizanidine, which may cause the drug to build up in your system.
FDA Label Information
7.2 Moderate or Weak CYP1A2 Inhibitors Concomitant use of tizanidine with moderate or weak CYP1A2 inhibitors (e.g., zileuton, antiarrhythmics [amiodarone, mexiletine, propafenone, and verapamil], cimetidine, famotidine, oral contraceptives, acyclovir, and ticlopidine) should be avoided.
Tizanidine Also Interacts With
- Ciprofloxacin major
- Fluvoxamine major
- Famotidine moderate
- Acyclovir minor
- Verapamil minor
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Tizanidine + Amiodarone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiodarone has 42 labeled pairs on file vs Tizanidine's 17. In the minor band specifically: Tizanidine has 14 (also Acyclovir, Verapamil, Propafenone, Mexiletine); Amiodarone has 29 (also Atorvastatin, Clonidine, Diltiazem, Verapamil).
What mechanism field is on file for Tizanidine and Amiodarone?
Amiodarone blocks the enzyme responsible for breaking down tizanidine, which may cause the drug to build up in your system.
Amiodarone carries more major-labeled pairs than Tizanidine
SPL source-record counts only. This page's band is minor · classes on file: Tizanidine (Central Alpha-2 Agonist (Muscle Relaxant)); Amiodarone (Class III Antiarrhythmic).
Amiodarone has 4 major-labeled pairs vs Tizanidine's 2. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 14 minor · 17 total
- Other minor peers for Tizanidine
- Acyclovir
- Verapamil
- Propafenone
- Mexiletine
4 major · 9 moderate · 29 minor · 42 total
- Other minor peers for Amiodarone
- Atorvastatin
- Clonidine
- Diltiazem
- Verapamil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.