Tizanidine and Fluvoxamine Interaction
Drug interaction information between Tizanidine and Fluvoxamine.
Tizanidine and Fluvoxamine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Tizanidine and Fluvoxamine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluvoxamine blocks the enzyme that normally clears tizanidine from your body. This leads to much higher amounts of tizanidine in your blood than intended.
FDA Label Information
( 7.2 , 12.3 ) 7.1 Strong CYP1A2 Inhibitors Concomitant use of tizanidine with strong cytochrome P450 1A2 (CYP1A2) inhibitors (e.g., fluvoxamine, ciprofloxacin) is contraindicated.
Tizanidine Also Interacts With
- Ciprofloxacin major
- Famotidine moderate
- Acyclovir minor
- Verapamil minor
- Amiodarone minor
Fluvoxamine Also Interacts With
- Lithium moderate
- Phenelzine moderate
- Tasimelteon moderate
- Metoprolol minor
- Omeprazole minor
Frequently Asked Questions
What SPL severity band is on file for Tizanidine + Fluvoxamine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluvoxamine has 40 labeled pairs on file vs Tizanidine's 17. In the major band specifically: Tizanidine has 2 (also Ciprofloxacin); Fluvoxamine has 1.
What mechanism field is on file for Tizanidine and Fluvoxamine?
Fluvoxamine blocks the enzyme that normally clears tizanidine from your body. This leads to much higher amounts of tizanidine in your blood than intended.
Tizanidine carries more major-labeled pairs than Fluvoxamine
SPL source-record counts only. This page's band is major · classes on file: Tizanidine (Central Alpha-2 Agonist (Muscle Relaxant)); Fluvoxamine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Tizanidine has 2 major-labeled pairs vs Fluvoxamine's 1.
2 major · 1 moderate · 14 minor · 17 total
- Other major peers for Tizanidine
- Ciprofloxacin
1 major · 3 moderate · 36 minor · 40 total
Fluvoxamine has no other major-band peer in this dataset besides Tizanidine.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.