Tizanidine and Propafenone Interaction
Drug interaction information between Tizanidine and Propafenone.
Tizanidine and Propafenone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tizanidine and Propafenone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Propafenone interferes with how your body processes tizanidine, making the drug stay in your blood longer than it should.
FDA Label Information
7.2 Moderate or Weak CYP1A2 Inhibitors Concomitant use of tizanidine with moderate or weak CYP1A2 inhibitors (e.g., zileuton, antiarrhythmics [amiodarone, mexiletine, propafenone, and verapamil], cimetidine, famotidine, oral contraceptives, acyclovir, and ticlopidine) should be avoided.
Tizanidine Also Interacts With
- Ciprofloxacin major
- Fluvoxamine major
- Famotidine moderate
- Acyclovir minor
- Verapamil minor
Propafenone Also Interacts With
- Nirmatrelvir/Ritonavir major
- Amiodarone moderate
- Fluoxetine moderate
- Nebivolol moderate
- Ketoconazole minor
Frequently Asked Questions
What SPL severity band is on file for Tizanidine + Propafenone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propafenone has 26 labeled pairs on file vs Tizanidine's 17. In the minor band specifically: Tizanidine has 14 (also Acyclovir, Verapamil, Amiodarone, Mexiletine); Propafenone has 22 (also Ketoconazole, Erythromycin, Desipramine, Cimetidine).
What mechanism field is on file for Tizanidine and Propafenone?
Propafenone interferes with how your body processes tizanidine, making the drug stay in your blood longer than it should.
Tizanidine carries more major-labeled pairs than Propafenone
SPL source-record counts only. This page's band is minor · classes on file: Tizanidine (Central Alpha-2 Agonist (Muscle Relaxant)); Propafenone (Class IC Antiarrhythmic).
Tizanidine has 2 major-labeled pairs vs Propafenone's 1. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 14 minor · 17 total
- Other minor peers for Tizanidine
- Acyclovir
- Verapamil
- Amiodarone
- Mexiletine
1 major · 3 moderate · 22 minor · 26 total
- Other minor peers for Propafenone
- Ketoconazole
- Erythromycin
- Desipramine
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.