Tizanidine and Verapamil Interaction
Drug interaction information between Tizanidine and Verapamil.
Tizanidine and Verapamil have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tizanidine and Verapamil. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Verapamil slows down the liver process that clears tizanidine from your body, which can lead to higher drug levels.
What To Do
You should avoid taking these two medications at the same time.
FDA Label Information
7.2 Moderate or Weak CYP1A2 Inhibitors Concomitant use of tizanidine with moderate or weak CYP1A2 inhibitors (e.g., zileuton, antiarrhythmics [amiodarone, mexiletine, propafenone, and verapamil], cimetidine, famotidine, oral contraceptives, acyclovir, and ticlopidine) should be avoided.
Tizanidine Also Interacts With
- Ciprofloxacin major
- Fluvoxamine major
- Famotidine moderate
- Acyclovir minor
- Amiodarone minor
Verapamil Also Interacts With
- Eplerenone major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Clarithromycin moderate
Frequently Asked Questions
Can I take Tizanidine and Verapamil together?
This is a minor interaction. You should avoid taking these two medications at the same time.
How serious is the interaction between Tizanidine and Verapamil?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Tizanidine and Verapamil interact?
Verapamil slows down the liver process that clears tizanidine from your body, which can lead to higher drug levels.
Understanding the Tizanidine and Verapamil Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Tizanidine belongs to the Central Alpha-2 Agonist (Muscle Relaxant) class and Verapamil belongs to the Calcium Channel Blocker class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Verapamil slows down the liver process that clears tizanidine from your body, which can lead to higher drug levels. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Tizanidine has 17 total documented interactions on file in this dataset, and Verapamil has 57. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You should avoid taking these two medications at the same time. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Tizanidine or Verapamil based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.